BetterThanSPY

Relative Intelligence · Pharmaceuticals

How Sanofi (SNY) compares with the whole market and its popular alternatives

Built by QuantCommons' quantitative engine, this page is about relative opportunity, not data on SNY alone. It places SNY (Sanofi) against 20+ popular alternatives, its neighboring categories and the entire market of over 10,000 U.S.-listed stocks and ETFs, and surfaces what has done better on consistent outperformance, return for the risk taken, behavior in real market crashes and diversification. The result is a clearer view of where SNY stands in the market, and of the alternatives worth a closer look.

Period covered: SNY's full trading record, from July 2002 through September 2026. The crash tests reach back to 2000 using older funds and the S&P 500. All returns include reinvested dividends. Data as of October 22, 2026.

Data as of October 22, 2026. Full tables and charts read best on a larger screen.

Rank the market against SNY →Chart SNY vs. 21 alternatives →

This page answers the following questions about SNY

Key findings

Not AI-generated

These key findings are generated by our proprietary relative intelligence engine, directly from the data on this page.

How much would $10,000 in SNY have grown?

This chart tracks a hypothetical $10,000 investment in SNY over the past 24 years, with dividends reinvested, alongside the same amount in the S&P 500, investments that ended ahead of SNY over the same span and SNY's popular alternatives, among those that traded for the entire period. A second view covers the past 5 years, the period the better options further down the page are judged on. It shows not only where each investment ended up but also how smooth or uneven the path was.

Choose a period

From the end of September 2002 to the end of September 2026. The scale is logarithmic, so equal steps up the chart are equal percentage gains. Hover over a fund in the key to pick out its line. 1,154 of the 1,370 stocks and funds worth at least $500 million that traded the whole period ended ahead of SNY; the chart shows 5, closest alternatives first. The other 3 lines are popular alternatives, shown for context.

$5,000$10,000$20,000$50,000$100,000$200,000$500,0002002200620102014201820222026$10,000$100,00020022008201420202026
  • REGN$567,172+5,572% total · +18.3% a year
  • GILD$521,150+5,112% total · +17.9% a year
  • TMO$443,241+4,332% total · +17.1% a year
  • LLY$404,698+3,947% total · +16.7% a year
  • AMGN$151,461+1,415% total · +12.0% a year
  • SPY (S&P 500)$144,215+1,342% total · +11.8% a year
  • JNJ$94,478+845% total · +9.8% a year
  • NVS$91,216+812% total · +9.6% a year
  • GSK$38,474+285% total · +5.8% a year
  • SNY$34,735+247% total · +5.3% a year
Change the dates or add tickers to this chart in EasyCompare

From the end of September 2021 to the end of September 2026. Hover over a fund in the key to pick out its line. 2,440 of the 3,630 stocks and funds worth at least $500 million that traded the whole period ended ahead of SNY; the chart shows 5, closest alternatives first. The other 3 lines are popular alternatives, shown for context.

$0$10,000$20,000$30,000$40,000$50,000$60,000202120222023202420252026$0$20,000$40,000$60,000202120222023202420252026
  • LLY$52,411+424% total · +39.3% a year
  • ABBV$29,134+191% total · +23.8% a year
  • AMGN$23,160+132% total · +18.3% a year
  • NVS$21,146+111% total · +16.2% a year
  • SPY (S&P 500)$19,000+90.0% total · +13.7% a year
  • JNJ$18,849+88.5% total · +13.5% a year
  • TAK$13,697+37.0% total · +6.5% a year
  • TMO$11,986+19.9% total · +3.7% a year
  • IQV$11,224+12.2% total · +2.3% a year
  • SNY$10,438+4.4% total · +0.9% a year
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SNY at a glance

This section summarizes the key facts about the stock, its returns over periods from one to ten years and the risk it has carried, with dividends reinvested throughout. These figures serve as the baseline for every comparison that follows.

The company

Market value
$101B
Industry
Drug Manufacturers - General
Price history from
July 2002

Returns

Past 1 year
−12.7%total return
Past 3 years
−8.8%−3.0% a year
Past 5 years
+2.6%+0.5% a year
Past 10 years
+65.1%+5.1% a year
Best calendar year
+36.0%2012
Worst calendar year
−26.5%2008
Losing years
5 of 23full calendar years

Risk

Volatility
25.4%typical yearly swing, 5 years
Sharpe ratio
0.15return per unit of risk, 5 years
Worst decline ever
−46.7%Jul 2006 to Mar 2009
From its all-time high
−23.4%below the peak

SNY against the whole market

Where SNY ranks among every stock and fund, and what across the market has done better.

How does SNY rank among all stocks?

This section ranks SNY on return, volatility, risk-adjusted return and worst decline against every stock worth at least $300 million with enough history. Where the comparisons with its popular alternatives show how SNY stacks up against its peers, these rankings show where it stands in the market as a whole.

Ranked against U.S.-listed stocks worth at least $300M that have enough history for each measure, so the count changes from row to row; smaller stocks are left out. Lower volatility and smaller declines rank higher.

MeasureSNYRankStanding
1-year return−12.7%2,463 of 3,282bottom 26%
3-year return−8.8%2,475 of 3,016bottom 19%
5-year return+2.6%1,699 of 2,897bottom 42%
10-year return+65.1%1,514 of 2,201bottom 32%
Volatility, 5 years25.4%356 of 2,897top 12%
Sharpe ratio, 5 years0.152,003 of 2,897bottom 32%
Worst decline, past 10 years−33.5%49 of 2,184top 2%

What has beaten SNY on both return and risk?

Each dot is an investment, placed by how much it earned a year over the past 5 years (higher is better) and how much its price swung, its volatility (further left is calmer). SNY sits where the dashed lines cross. Anything in the green box above and to the left earned more than SNY with smaller swings, a better trade-off over this period on both counts. Past results are no promise, but a name in the box is worth a closer look.

Annual return is the annualized total return with dividends reinvested, and volatility the annualized swing in daily prices, both over 5 years. Labeled dots are the strongest picks from the table below and the names called out above, colored by how close they sit to SNY; faint dots are 90 more of the 911 in the green region (the strongest, one per fund family). 3,641 stocks and funds worth at least $500 million were screened. Hover over a dot for its figures.

−5.0%0.0%5.0%10.0%15.0%20.0%25.0%30.0%−5.0%0.0%5.0%10.0%15.0%20.0%25.0%30.0%Volatility over 5 years (annualized)Annual return over 5 yearsMore return, less volatility than SNYVRIG: +4.7% a year, volatility 1.3%BALT: +6.2% a year, volatility 3.3%FLRT: +6.0% a year, volatility 2.3%PG: +5.8% a year, volatility 18.4%AOM: +4.4% a year, volatility 8.3%FLOT: +4.5% a year, volatility 1.8%VTIP: +2.7% a year, volatility 2.9%EP-PC: +5.2% a year, volatility 8.9%DFAC: +11.3% a year, volatility 17.0%FJAN: +11.0% a year, volatility 10.5%POCT: +9.9% a year, volatility 8.0%BSV: +1.8% a year, volatility 2.8%VCSH: +2.4% a year, volatility 2.9%JEPI: +7.3% a year, volatility 11.0%SHY: +1.9% a year, volatility 2.0%DOCT: +8.2% a year, volatility 7.4%XLV: +8.4% a year, volatility 15.3%VNLA: +4.1% a year, volatility 1.1%FLTR: +4.8% a year, volatility 2.1%FLRN: +4.5% a year, volatility 1.7%DFIV: +14.8% a year, volatility 16.4%AVLV: +13.9% a year, volatility 16.9%FLDR: +3.9% a year, volatility 1.2%STIP: +2.7% a year, volatility 2.8%DFAT: +9.7% a year, volatility 21.0%DFAS: +7.2% a year, volatility 20.5%TBUX: +4.2% a year, volatility 1.1%SUB: +1.5% a year, volatility 1.7%RAVI: +3.8% a year, volatility 1.4%DFAI: +9.6% a year, volatility 16.0%RY: +17.5% a year, volatility 18.2%BUFR: +9.8% a year, volatility 10.5%USTB: +3.6% a year, volatility 2.1%LMBS: +3.1% a year, volatility 2.6%BKLN: +5.3% a year, volatility 4.5%XLP: +7.6% a year, volatility 13.8%SRLN: +4.6% a year, volatility 3.9%DFAX: +9.6% a year, volatility 16.1%SPHY: +3.8% a year, volatility 7.2%FTSL: +5.0% a year, volatility 3.4%JAVA: +11.4% a year, volatility 14.5%CCZ: +4.6% a year, volatility 22.6%BKLC: +13.6% a year, volatility 17.3%QYLD: +8.2% a year, volatility 15.0%FLUD: +3.9% a year, volatility 1.4%DBMF: +9.5% a year, volatility 12.4%MPLX: +24.0% a year, volatility 18.8%EFAV: +7.7% a year, volatility 11.9%FTLS: +10.1% a year, volatility 10.5%PTLC: +9.3% a year, volatility 11.9%DIVI: +13.3% a year, volatility 15.5%PECO: +8.2% a year, volatility 22.3%BSCR: +1.8% a year, volatility 4.1%ACIO: +9.1% a year, volatility 11.2%SCHY: +9.5% a year, volatility 13.3%LDUR: +2.4% a year, volatility 2.1%STOT: +2.9% a year, volatility 1.7%UCON: +2.3% a year, volatility 4.0%EMLC: +2.5% a year, volatility 9.1%SMMU: +2.0% a year, volatility 1.7%FJUN: +10.4% a year, volatility 10.6%FLBL: +5.2% a year, volatility 3.9%QDPL: +11.6% a year, volatility 15.0%JPIB: +2.6% a year, volatility 4.2%BRK-A: +13.5% a year, volatility 17.2%FFLC: +15.5% a year, volatility 16.8%INFL: +11.6% a year, volatility 17.8%FPEI: +3.4% a year, volatility 6.0%TDVG: +9.5% a year, volatility 13.8%LQDH: +5.2% a year, volatility 4.4%FLMI: +1.6% a year, volatility 4.6%PTNQ: +9.4% a year, volatility 14.2%EFIV: +13.0% a year, volatility 17.1%FTQI: +11.4% a year, volatility 14.8%TIPX: +1.6% a year, volatility 4.7%AVES: +7.7% a year, volatility 17.5%PJUN: +6.8% a year, volatility 8.3%FLSP: +8.6% a year, volatility 13.4%SIXH: +10.3% a year, volatility 10.3%SMIG: +6.5% a year, volatility 16.0%V: +13.2% a year, volatility 22.9%SIXA: +12.9% a year, volatility 12.7%QAI: +4.1% a year, volatility 6.8%QSPT: +11.9% a year, volatility 14.9%KO: +15.2% a year, volatility 16.8%COST: +17.4% a year, volatility 22.9%DRSK: +2.1% a year, volatility 7.5%BSJR: +3.4% a year, volatility 6.7%MA: +12.7% a year, volatility 23.8%QQQ: +14.2% a year, volatility 23.0%SNY: +0.5% a year, volatility 25.4%SPY (S&P 500): +12.5% a year, volatility 17.2%JNJ: +13.5% a year, volatility 18.0%NVS: +17.4% a year, volatility 20.7%AMGN: +20.1% a year, volatility 24.9%ABBV: +25.5% a year, volatility 23.4%TAK: +12.3% a year, volatility 19.4%GILD: +22.8% a year, volatility 24.9%RPRX: +13.8% a year, volatility 23.8%IBB: +6.0% a year, volatility 22.4%RDY: +2.3% a year, volatility 23.7%IHE: +12.9% a year, volatility 16.8%FBT: +10.8% a year, volatility 22.2%INVA: +5.3% a year, volatility 26.9%SGOV: +3.8% a year, volatility 0.3%GLD: +17.1% a year, volatility 19.0%JAAA: +5.1% a year, volatility 1.7%CHT: +8.2% a year, volatility 13.3%HYGH: +6.6% a year, volatility 7.1%WMT: +21.1% a year, volatility 22.6%DTM: +25.0% a year, volatility 25.2%IAGG: +1.2% a year, volatility 4.5%WELL: +27.0% a year, volatility 23.8%DXJ: +26.6% a year, volatility 19.1%SNYSPY (S&P 500)JNJNVSAMGNABBVGILDRPRXIBBRDYFBTINVASGOVGLDCHTHYGHWMTDTMIAGGWELLDXJ−10.0%0.0%10.0%20.0%30.0%−5.0%0.0%5.0%10.0%15.0%20.0%25.0%30.0%Volatility over 5 years (annualized)Annual return over 5 yearsMore return, less volatility than SNYVRIG: +4.7% a year, volatility 1.3%BALT: +6.2% a year, volatility 3.3%FLRT: +6.0% a year, volatility 2.3%PG: +5.8% a year, volatility 18.4%AOM: +4.4% a year, volatility 8.3%FLOT: +4.5% a year, volatility 1.8%VTIP: +2.7% a year, volatility 2.9%EP-PC: +5.2% a year, volatility 8.9%DFAC: +11.3% a year, volatility 17.0%FJAN: +11.0% a year, volatility 10.5%POCT: +9.9% a year, volatility 8.0%BSV: +1.8% a year, volatility 2.8%VCSH: +2.4% a year, volatility 2.9%JEPI: +7.3% a year, volatility 11.0%SHY: +1.9% a year, volatility 2.0%DOCT: +8.2% a year, volatility 7.4%XLV: +8.4% a year, volatility 15.3%VNLA: +4.1% a year, volatility 1.1%FLTR: +4.8% a year, volatility 2.1%FLRN: +4.5% a year, volatility 1.7%DFIV: +14.8% a year, volatility 16.4%AVLV: +13.9% a year, volatility 16.9%FLDR: +3.9% a year, volatility 1.2%STIP: +2.7% a year, volatility 2.8%DFAT: +9.7% a year, volatility 21.0%DFAS: +7.2% a year, volatility 20.5%TBUX: +4.2% a year, volatility 1.1%SUB: +1.5% a year, volatility 1.7%RAVI: +3.8% a year, volatility 1.4%DFAI: +9.6% a year, volatility 16.0%RY: +17.5% a year, volatility 18.2%BUFR: +9.8% a year, volatility 10.5%USTB: +3.6% a year, volatility 2.1%LMBS: +3.1% a year, volatility 2.6%BKLN: +5.3% a year, volatility 4.5%XLP: +7.6% a year, volatility 13.8%SRLN: +4.6% a year, volatility 3.9%DFAX: +9.6% a year, volatility 16.1%SPHY: +3.8% a year, volatility 7.2%FTSL: +5.0% a year, volatility 3.4%JAVA: +11.4% a year, volatility 14.5%CCZ: +4.6% a year, volatility 22.6%BKLC: +13.6% a year, volatility 17.3%QYLD: +8.2% a year, volatility 15.0%FLUD: +3.9% a year, volatility 1.4%DBMF: +9.5% a year, volatility 12.4%MPLX: +24.0% a year, volatility 18.8%EFAV: +7.7% a year, volatility 11.9%FTLS: +10.1% a year, volatility 10.5%PTLC: +9.3% a year, volatility 11.9%DIVI: +13.3% a year, volatility 15.5%PECO: +8.2% a year, volatility 22.3%BSCR: +1.8% a year, volatility 4.1%ACIO: +9.1% a year, volatility 11.2%SCHY: +9.5% a year, volatility 13.3%LDUR: +2.4% a year, volatility 2.1%STOT: +2.9% a year, volatility 1.7%UCON: +2.3% a year, volatility 4.0%EMLC: +2.5% a year, volatility 9.1%SMMU: +2.0% a year, volatility 1.7%FJUN: +10.4% a year, volatility 10.6%FLBL: +5.2% a year, volatility 3.9%QDPL: +11.6% a year, volatility 15.0%JPIB: +2.6% a year, volatility 4.2%BRK-A: +13.5% a year, volatility 17.2%FFLC: +15.5% a year, volatility 16.8%INFL: +11.6% a year, volatility 17.8%FPEI: +3.4% a year, volatility 6.0%TDVG: +9.5% a year, volatility 13.8%LQDH: +5.2% a year, volatility 4.4%FLMI: +1.6% a year, volatility 4.6%PTNQ: +9.4% a year, volatility 14.2%EFIV: +13.0% a year, volatility 17.1%FTQI: +11.4% a year, volatility 14.8%TIPX: +1.6% a year, volatility 4.7%AVES: +7.7% a year, volatility 17.5%PJUN: +6.8% a year, volatility 8.3%FLSP: +8.6% a year, volatility 13.4%SIXH: +10.3% a year, volatility 10.3%SMIG: +6.5% a year, volatility 16.0%V: +13.2% a year, volatility 22.9%SIXA: +12.9% a year, volatility 12.7%QAI: +4.1% a year, volatility 6.8%QSPT: +11.9% a year, volatility 14.9%KO: +15.2% a year, volatility 16.8%COST: +17.4% a year, volatility 22.9%DRSK: +2.1% a year, volatility 7.5%BSJR: +3.4% a year, volatility 6.7%MA: +12.7% a year, volatility 23.8%QQQ: +14.2% a year, volatility 23.0%SNY: +0.5% a year, volatility 25.4%SPY (S&P 500): +12.5% a year, volatility 17.2%JNJ: +13.5% a year, volatility 18.0%NVS: +17.4% a year, volatility 20.7%AMGN: +20.1% a year, volatility 24.9%ABBV: +25.5% a year, volatility 23.4%TAK: +12.3% a year, volatility 19.4%GILD: +22.8% a year, volatility 24.9%RPRX: +13.8% a year, volatility 23.8%IBB: +6.0% a year, volatility 22.4%RDY: +2.3% a year, volatility 23.7%IHE: +12.9% a year, volatility 16.8%FBT: +10.8% a year, volatility 22.2%INVA: +5.3% a year, volatility 26.9%SGOV: +3.8% a year, volatility 0.3%GLD: +17.1% a year, volatility 19.0%JAAA: +5.1% a year, volatility 1.7%CHT: +8.2% a year, volatility 13.3%HYGH: +6.6% a year, volatility 7.1%WMT: +21.1% a year, volatility 22.6%DTM: +25.0% a year, volatility 25.2%IAGG: +1.2% a year, volatility 4.5%WELL: +27.0% a year, volatility 23.8%DXJ: +26.6% a year, volatility 19.1%SNYSPY (S&P 500)JNJNVSAMGNABBVGILDIBBRDYFBTSGOVGLDJAAACHTHYGHWMTDTMIAGGWELLDXJ
  • Popular alternatives
  • Same and neighboring categories, and shared themes
  • The whole market
  • Others in the green region

Is there a better investment than SNY?

Investments that beat SNY over the past 5 years on return, volatility, drawdowns, consistency, crash losses or fees, from its popular alternatives out to the whole market.

How this works

The table below lists investments that beat SNY over the past 5 years on at least one of these measures: a higher annual return with lower volatility, a higher annual return at similar volatility, a similar return with lower volatility, a higher Sharpe ratio with a smaller worst decline, a higher total return in most periods from 3 months to 10 years, or smaller losses in recent market crashes. It checks SNY's popular alternatives first, then the rest of its own and neighboring categories, then every stock and fund worth at least $500 million, and shows the strongest few in each group. The full list of those with a higher return and lower volatility than SNY follows the table.

Annual return is the annualized total return with dividends reinvested. Annual return, volatility and the Sharpe ratio cover 5 years; the worst decline covers the past 10 years. Green marks a better figure than SNY's. "On the frontier" means no other option shown or tested earned more with less volatility. Funds that hold the same thing are shown once. Beyond the popular alternatives, nothing with more than 1.5× SNY's volatility counts as better.

These figures cover the past 5 years. Green marks a better figure than SNY's.

Screen the whole market against SNY for any period in BetterThanSPYOpen these 21 in EasyCompare
InvestmentWhy it is betterPast 5 yearsDownsideLong runFit
Annual return?higher is betterVolatility?lower is calmerSharpe?return per unit of riskWorst decline?past 10 years10Y returntotalCorr. with SNY?lower diversifies moreExpenseper year
SNYSanofi · this page
+0.5%25.4%0.15−33.5%+65.1%1.00—
SPYState Street SPDR S&P 500 ETF · S&P 500
+12.5%17.2%0.78−33.7%+316%0.250.09%
Popular alternativesbest 6 shownThe investments people most often weigh against SNY. 17 of 21 passed at least one test.
JNJJohnson & Johnson · Pharmaceuticals
Higher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periods+13.5%18.0%0.80−27.4%+209%0.35—
NVSNovartis AG · Pharmaceuticals
Higher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periods+17.4%20.7%0.89−26.8%+234%0.58—
AMGNAmgen Inc. · Biotechnology
Higher return, similar volatilityHigher Sharpe, smaller worst declineHigher return in most periods+20.1%24.9%0.86−24.9%+280%0.46—
ABBVAbbVie Inc. · Specialty Pharmaceuticals
Higher return, lower volatilityHigher return in most periods+25.5%23.4%1.09−45.1%+600%0.30—
TAKTakeda Pharmaceutical Company Limited · Specialty Pharmaceuticals
Higher return, lower volatilityHigher return in most periods+12.3%19.4%0.70−54.4%+33.3%0.44—
GILDGilead Sciences, Inc. · Biotechnology
Higher return, similar volatilityHigher return in most periods+22.8%24.9%0.95−30.5%+202%0.22—
Same and neighboring categories, and shared themesbest 6 shownEverything else in Pharmaceuticals and the categories next to it (Biotechnology, Specialty Pharmaceuticals), plus SNY's specific themes. 20 of 256 passed at least one test.
RPRXRoyalty Pharma plc · Pharmaceuticals
Higher return, lower volatilityHigher return in most periods+13.8%23.8%0.67−49.7%—0.26—
IBBiShares Biotechnology ETF · Biotechnology
Higher return, lower volatilityHigher return in most periods+6.0%22.4%0.37−39.8%+142%0.300.44%
RDYDr. Reddy's Laboratories Limited · Pharmaceuticals
Higher return, lower volatilityHigher return in most periods+2.3%23.7%0.21−40.5%+58.3%0.04—
IHEiShares U.S. Pharmaceuticals ETF · Pharmaceuticals
Higher return, lower volatilityHigher return in most periods+12.9%16.8%0.81−29.6%+157%0.450.37%
FBTFirst Trust NYSE Arca Biotechnology Index Fund · Biotechnology
Higher return, lower volatilityHigher return in most periods+10.8%22.2%0.58−33.3%+205%0.360.55%
INVAInnoviva, Inc. · Biotechnology
Higher return, similar volatilityHigher return in most periods+5.3%26.9%0.33−59.6%+110%0.33—
The whole marketbest 8 shownEvery other stock and fund worth at least $500 million. 1,789 of 3,430 passed at least one test.
SGOViShares 0-3 Month Treasury Bond ETF · Treasury Bills
On the frontierHigher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periods+3.8%0.3%13.25−0.3%—0.090.09%
GLDSPDR Gold Shares · Gold
Higher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periodsSmaller losses in recent crashes+17.1%19.0%0.93−26.4%+206%0.250.40%
JAAAJanus Henderson AAA CLO ETF · AAA CLO Debt
On the frontierHigher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periods+5.1%1.7%2.98−2.6%—-0.080.20%
CHTChunghwa Telecom Co., Ltd. · Integrated Telecommunications
Higher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periodsSmaller losses in recent crashes+8.2%13.3%0.66−23.8%+104%0.18—
HYGHiShares Interest Rate Hedged High Yield Bond ETF · High Yield Bonds
On the frontierHigher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periodsSmaller losses in recent crashes+6.6%7.1%0.95−23.9%+73.7%0.271.12%
WMTWalmart Inc. · Discount Retail
Higher return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periods+21.1%22.6%0.97−25.7%+521%0.10—
DTMDT Midstream, Inc. · Oil & Gas Midstream
Higher return, similar volatilityHigher Sharpe, smaller worst declineHigher return in most periods+25.0%25.2%1.02−23.6%—0.10—
IAGGiShares Core International Aggregate Bond ETF · International Bonds
Similar return, lower volatilityHigher Sharpe, smaller worst declineHigher return in most periods+1.2%4.5%0.28−13.9%+21.7%0.350.07%
What these numbers mean for SNY
Annual return
SNY returned 0.5% a year over the past 5 years with dividends reinvested, against 12.5% a year for the S&P 500. At that pace, $10,000 became about $10,300. Annual return is the steady yearly rate that would produce the same total result, so investments held over the same span compare fairly. Guide: What is performance and return? →
Volatility
SNY's volatility over the past 5 years was 25.4%, 1.5 times the S&P 500's 17.2%. Volatility measures how widely returns swing around their average: in roughly two years out of three, SNY's return lands within 25.4% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump. Guide: Understanding and measuring risk (volatility) →
Sharpe ratio
SNY's Sharpe ratio over the past 5 years was 0.15, against 0.78 for the S&P 500, so SNY earned less for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings. Guide: Balancing reward with risk (Sharpe ratio) →
Worst decline
SNY's worst fall from a peak to a low over the past 10 years was 33.5%, against 33.7% for the S&P 500. Losses and gains are not symmetric: climbing back from a 33.5% fall takes a 50.4% gain. Guide: Market crash risk and tail risk →
Correlation
Over the past 5 years, SNY's monthly returns had a correlation of 0.25 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They are only loosely linked, which makes it a real diversifier next to an index fund. In the table, the correlation column measures each option against SNY instead: the lower it is, the more that option would diversify a SNY holding. Guide: Correlation and diversification →
Show all 911 stocks and funds worth at least $500 million that earned more than SNY with less volatility

Out of 3,641 tested over 5 years. The strongest 100 are listed, best first, with funds that hold the same thing listed once.

#InvestmentFound inAnnual returnVolatilitySharpeWorst decline10Y returnCorr. with SNYExpense
1
SGOViShares 0-3 Month Treasury Bond ETF · Treasury Bills
Whole market+3.8%0.3%13.25−0.3%—0.090.09%
2
GLDSPDR Gold Shares · Gold
Whole market+17.1%19.0%0.93−26.4%+206%0.250.40%
3
JAAAJanus Henderson AAA CLO ETF · AAA CLO Debt
Whole market+5.1%1.7%2.98−2.6%—-0.080.20%
4
CHTChunghwa Telecom Co., Ltd. · Integrated Telecommunications
Whole market+8.2%13.3%0.66−23.8%+104%0.18—
5
HYGHiShares Interest Rate Hedged High Yield Bond ETF · High Yield Bonds
Whole market+6.6%7.1%0.95−23.9%+73.7%0.271.12%
6
WMTWalmart Inc. · Discount Retail
Whole market+21.1%22.6%0.97−25.7%+521%0.10—
7
VRIGInvesco Variable Rate Investment Grade ETF · Investment Grade Bonds
Whole market+4.7%1.3%3.52−13.1%+40.7%-0.110.30%
8
BALTInnovator Defined Wealth Shield ETF · US Equity Buffer
Whole market+6.2%3.3%1.84−4.9%—0.210.69%
9
FLRTPacer Aristotle Pacific Floating Rate High Income ETF · Bank Loans
Whole market+6.0%2.3%2.55−20.9%+58.7%0.060.60%
10
PGThe Procter & Gamble Company · Household & Personal Products
Whole market+5.8%18.4%0.40−23.8%+156%0.25—
11
AOMiShares Core 40/60 Moderate Allocation ETF · Balanced Allocation
Whole market+4.4%8.3%0.56−20.0%+77.8%0.390.20%
12
FLOTiShares Floating Rate Bond ETF · Floating Rate Bonds
Whole market+4.5%1.8%2.49−13.5%+35.9%-0.120.15%
13
VTIPVanguard Short-Term Inflation-Protected Securities ETF · Inflation-Protected Bonds
Whole market+2.7%2.9%0.95−6.3%+33.2%0.530.03%
14
EP-PCEl Paso Energy Capital Trust I PFD CV TR SECS · Preferred Stocks
Whole market+5.2%8.9%0.62−25.4%+38.1%0.00—
15
DFACDimensional - US Core Equity 2 ETF · US Total Market
Whole market+11.3%17.0%0.72−23.1%—0.270.21%
16
FJANFT Vest U.S. Equity Buffer ETF - January · US Equity Buffer
Whole market+11.0%10.5%1.04−13.6%—0.280.85%
17
POCTInnovator U.S. Equity Power Buffer ETF · Moderate Buffer
Whole market+9.9%8.0%1.22−18.8%—0.220.79%
18
BSVVanguard Short-Term Bond ETF · Short-Term Bonds
Whole market+1.8%2.8%0.67−8.5%+21.0%0.490.03%
19
VCSHVanguard Short-Term Corporate Bond ETF · Short-Term Corporate Bonds
Whole market+2.4%2.9%0.84−12.9%+29.1%0.460.03%
20
JEPIJPMorgan Equity Premium Income ETF · Covered Call Income
Whole market+7.3%11.0%0.70−13.7%—0.400.35%
21
SHYiShares 1-3 Year Treasury Bond ETF · Short-Term Treasuries
Whole market+1.9%2.0%0.93−5.7%+18.0%0.480.15%
22
DOCTFT Vest U.S. Equity Deep Buffer ETF - October · Deep Buffer
Whole market+8.2%7.4%1.10−9.9%—0.200.85%
23
XLVState Street Health Care Select Sector SPDR ETF · Health Care Equity
Whole market+8.4%15.3%0.60−28.4%+208%0.510.08%
24
VNLAJanus Henderson Short Duration Income ETF · Ultrashort Bonds
Whole market+4.1%1.1%3.80−4.5%—0.150.25%
25
FLTRVanEck IG Floating Rate ETF · Floating Rate Bonds
Whole market+4.8%2.1%2.21−17.8%+42.1%-0.190.14%
26
FLRNState Street SPDR Bloomberg Investment Grade Floating Rate ETF · Floating Rate Bonds
Whole market+4.5%1.7%2.58−14.7%+35.7%-0.060.15%
27
DFIVDimensional - International Value ETF · International Large-Cap Value
Whole market+14.8%16.4%0.93−25.4%—0.470.27%
28
AVLVAvantis U.S. Large Cap Value ETF · US Large-Cap Value
Whole market+13.9%16.9%0.86−19.5%—0.290.15%
29
FLDRFidelity Low Duration Bond Factor ETF · Short-Term Bonds
Whole market+3.9%1.2%3.13−12.2%—0.250.15%
30
STIPiShares 0-5 Year TIPS Bond ETF · Inflation-Protected Bonds
Whole market+2.7%2.8%0.95−6.5%+33.0%0.540.03%
31
DFATDimensional - US Targeted Value ETF · US Small-Cap Value
Whole market+9.7%21.0%0.55−26.1%—0.270.33%
32
DFASDimensional - US Small Cap ETF · Systematic Core Equity
Whole market+7.2%20.5%0.44−26.1%—0.240.31%
33
TBUXT. Rowe Price Ultra Short-Term Bond ETF · Ultrashort Bonds
Whole market+4.2%1.1%3.88−1.8%—0.180.17%
34
SUBiShares Short-Term National Muni Bond ETF · Short-Term Municipal Bonds
Whole market+1.5%1.7%0.91−9.4%+16.2%0.380.07%
35
RAVINorthern Trust Ultra-Short Fixed Income ETF · Ultrashort Bonds
Whole market+3.8%1.4%2.62−3.7%+31.1%0.090.26%
36
DFAIDimensional - International Core Equity Market ETF · Developed International Equity
Whole market+9.6%16.0%0.66−27.4%—0.470.18%
37
RYRoyal Bank of Canada · Banks
Whole market+17.5%18.2%0.98−40.0%+361%0.30—
38
BUFRFT Vest Laddered Buffer ETF · Buffered Equity
Whole market+9.8%10.5%0.95−13.7%—0.290.10%
39
USTBVictoryShares Short-Term Bond ETF · Short-Term Bonds
Whole market+3.6%2.1%1.77−5.3%—0.410.34%
40
LMBSFirst Trust Low Duration Opportunities ETF · Mortgage-Backed Securities
Whole market+3.1%2.6%1.17−6.5%+25.9%0.380.66%
41
BKLNInvesco Senior Loan ETF · Bank Loans
Whole market+5.3%4.5%1.19−24.1%+50.5%0.210.67%
42
WELLWelltower Inc. · Healthcare REITs
Whole market+27.0%23.8%1.13−63.3%+378%0.17—
43
XLPState Street Consumer Staples Select Sector SPDR ETF · Consumer Staples
Whole market+7.6%13.8%0.60−24.5%+124%0.380.08%
44
JNJJohnson & Johnson · Pharmaceuticals
Popular alternative+13.5%18.0%0.80−27.4%+209%0.35—
45
SRLNState Street Blackstone Senior Loan ETF · Bank Loans
Whole market+4.6%3.9%1.17−22.3%+53.9%0.110.70%
46
DFAXDimensional World ex U.S. Core Equity 2 ETF · International Equity
Whole market+9.6%16.1%0.65−28.1%—0.410.28%
47
NVSNovartis AG · Pharmaceuticals
Popular alternative+17.4%20.7%0.89−26.8%+234%0.58—
48
SPHYState Street SPDR Portfolio High Yield Bond ETF · High Yield Bonds
Whole market+3.8%7.2%0.56−22.0%+55.1%0.430.05%
49
FTSLFirst Trust Senior Loan Fund · Bank Loans
Whole market+5.0%3.4%1.49−22.7%+52.0%0.140.70%
50
JAVAJPMorgan Active Value ETF · US Large-Cap Value
Whole market+11.4%14.5%0.82−16.5%——0.44%
51
CCZComcast Holdings Corp. · Exchange-Traded Debt
Whole market+4.6%22.6%0.32−24.7%+81.0%0.08—
52
BKLCBNY Mellon US Large Cap Core Equity ETF · US Large-Cap Equity
Whole market+13.6%17.3%0.83−26.2%—0.220.00%
53
QYLDGlobal X - Nasdaq 100 Covered Call ETF · Covered Call Income
Whole market+8.2%15.0%0.60−24.7%+151%0.210.60%
54
FLUDFranklin Ultra Short Bond ETF · Ultrashort Bonds
Whole market+3.9%1.4%2.77−1.7%—0.100.15%
55
DBMFiMGP DBi Managed Futures Strategy ETF · Managed Futures
Whole market+9.5%12.4%0.80−20.4%—-0.210.85%
56
MPLXMPLX Lp · Oil & Gas Midstream
Whole market+24.0%18.8%1.25−75.2%+337%0.18—
57
EFAViShares MSCI EAFE Min Vol Factor ETF · International Equity
Whole market+7.7%11.9%0.69−27.6%+100%0.510.20%
58
FTLSFirst Trust Long/Short Equity ETF · Long-Short Equity
Whole market+10.1%10.5%0.97−20.6%+155%0.280.95%
59
PTLCPacer Trendpilot US Large Cap ETF · Tactical Equity
Whole market+9.3%11.9%0.81−26.6%+185%0.170.60%
60
DIVIFranklin International Core Dividend Tilt Index ETF · International Dividend Equity
Whole market+13.3%15.5%0.89−27.7%+182%0.480.09%
61
PECOPhillips Edison & Co. · Retail REITs
Whole market+8.2%22.3%0.47−23.1%—0.14—
62
BSCRInvesco BulletShares 2027 Corporate Bond ETF · Defined Maturity Corporate Bonds
Whole market+1.8%4.1%0.46−17.3%—0.420.10%
63
ACIOAptus Collared Income Opportunity ETF · Hedged Equity
Whole market+9.1%11.2%0.84−14.2%—0.240.79%
64
SCHYSchwab International Dividend Equity ETF · International Dividend Equity
Whole market+9.5%13.3%0.76−24.0%—0.540.08%
65
LDURPIMCO Enhanced Low Duration Active Exchange-Traded Fund · Short-Term Bonds
Whole market+2.4%2.1%1.16−8.7%+26.7%0.370.54%
66
STOTState Street DoubleLine Short Duration Total Return Tactical ETF · Short-Term Bonds
Whole market+2.9%1.7%1.69−6.1%+25.9%0.240.45%
67
UCONFirst Trust Smith Unconstrained Bond ETF · Multisector Bonds
Whole market+2.3%4.0%0.60−15.3%—0.390.86%
68
EMLCVanEck J.P. Morgan EM Local Currency Bond ETF · Emerging Market Bonds
Whole market+2.5%9.1%0.32−26.4%+17.7%0.400.30%
69
SMMUPIMCO Short Term Municipal Bond Active Exchange-Traded Fund · Short-Term Municipal Bonds
Whole market+2.0%1.7%1.16−5.1%+20.5%0.350.35%
70
FJUNFT Vest U.S. Equity Buffer ETF - June · S&P 500 Buffer
Whole market+10.4%10.6%0.99−13.3%—0.280.85%
71
FLBLFranklin Senior Loan ETF · Bank Loans
Whole market+5.2%3.9%1.35−19.5%—0.110.45%
72
QDPLPacer Metaurus US Large Cap Dividend Multiplier 400 ETF · US Dividend Equity
Whole market+11.6%15.0%0.81−22.6%—0.230.60%
73
JPIBJPMorgan International Bond Opportunities ETF · International Bonds
Whole market+2.6%4.2%0.63−13.1%—0.350.50%
74
BRK-ABerkshire Hathaway Inc. · Insurance
Whole market+13.5%17.2%0.83−30.4%+281%0.36—
75
FFLCFidelity Fundamental Large Cap Core ETF · Active Core Equity
Whole market+15.5%16.8%0.94−19.7%—0.270.38%
76
INFLHorizon Kinetics Inflation Beneficiaries ETF · Global Equity
Whole market+11.6%17.8%0.71−21.3%—0.340.85%
77
FPEIFirst Trust Institutional Preferred Securities & Income ETF · Preferred Securities
Whole market+3.4%6.0%0.58−27.5%—0.130.85%
78
TDVGT. Rowe Price Dividend Growth ETF · Dividend Growth
Whole market+9.5%13.8%0.73−19.2%—0.350.50%
79
LQDHiShares Interest Rate Hedged Corporate Bond ETF · Investment Grade Bonds
Whole market+5.2%4.4%1.20−24.6%+55.7%0.200.44%
80
FLMIFranklin Dynamic Municipal Bond ETF · Municipal Bonds
Whole market+1.6%4.6%0.36−14.6%—0.320.30%
81
PTNQPacer Trendpilot 100 ETF · Tactical Asset Allocation
Whole market+9.4%14.2%0.70−28.1%+292%0.180.65%
82
EFIVState Street SPDR S&P 500 ESG ETF · Large-Cap ESG
Whole market+13.0%17.1%0.81−24.5%—0.250.10%
83
FTQIFirst Trust Nasdaq BuyWrite Income ETF · Nasdaq Options Income
Whole market+11.4%14.8%0.81−19.5%+118%0.190.75%
84
TIPXState Street SPDR Bloomberg 1-10 Year TIPS ETF · Inflation-Protected Bonds
Whole market+1.6%4.7%0.36−10.1%+31.3%0.510.15%
85
AVESAvantis Emerging Markets Value ETF · International Equity
Whole market+7.7%17.5%0.51−27.4%—0.260.36%
86
PJUNInnovator U.S. Equity Power Buffer ETF - June · S&P 500 Buffer
Whole market+6.8%8.3%0.83−16.3%—0.260.79%
87
FLSPFranklin Systematic Style Premia ETF · Liquid Alternatives
Whole market+8.6%13.4%0.69−22.9%—0.050.65%
88
SIXHETC 6 Meridian Hedged Equity Index Option ETF · Hedged Equity
Whole market+10.3%10.3%1.01−11.7%—0.430.31%
89
SMIGBahl & Gaynor Small/Mid Cap Income Growth ETF · US Dividend Equity
Whole market+6.5%16.0%0.48−19.7%—0.290.60%
90
VVisa Inc. · Payment Processing
Whole market+13.2%22.9%0.66−36.4%+435%0.34—
91
SIXAETC 6 Meridian Mega Cap Equity ETF · US Large-Cap Equity
Whole market+12.9%12.7%1.02−18.4%—0.420.31%
92
QAINYLI Hedge Multi-Strategy Tracker ETF · Liquid Alternatives
Whole market+4.1%6.8%0.63−14.9%+43.6%0.270.75%
93
QSPTFT Vest Nasdaq-100 Buffer ETF - September · Nasdaq-100 Buffer
Whole market+11.9%14.9%0.83−22.6%—0.180.90%
94
DXJWisdomTree Japan Hedged Equity Fund · Japan Equity
Whole market+26.6%19.1%1.34−39.1%+415%0.120.48%
95
KOThe Coca-Cola Company · Nonalcoholic Beverages
Whole market+15.2%16.8%0.93−37.0%+205%0.49—
96
COSTCostco Wholesale Corporation · Discount Retail
Whole market+17.4%22.9%0.82−31.4%+692%0.14—
97
DRSKAptus Defined Risk ETF · Balanced Allocation
Whole market+2.1%7.5%0.32−19.9%—0.350.79%
98
BSJRInvesco BulletShares 2027 High Yield Corporate Bond ETF · High Yield Bonds
Whole market+3.4%6.7%0.54−22.6%—0.440.42%
99
MAMastercard Incorporated · Payment Processing
Whole market+12.7%23.8%0.62−41.0%+551%0.45—
100
QQQInvesco QQQ Trust, Series 1 · US Large-Cap Growth
Whole market+14.2%23.0%0.69−35.1%+531%0.120.18%

SNY against its popular alternatives

The investments people most often weigh against SNY, compared period by period and year by year.

How do SNY's risk and return compare with its alternatives?

This map plots each investment's annual return over the past 5 years against its volatility, the size of its typical price swings. Investments toward the upper left earned more for a smoother ride, and those toward the lower right earned less for a rougher one. The dashed lines cross at SNY, which divides the map into what did better or worse on each measure.

Green points earned more than SNY with less volatility; red points earned less with more. Hover over a point for its figures. Total returns with dividends reinvested, annualized.

15.0%20.0%25.0%30.0%35.0%40.0%45.0%50.0%55.0%−30.0%−20.0%−10.0%0.0%10.0%20.0%30.0%40.0%50.0%Volatility over 5 years (annualized)Annual return over 5 yearsHigher return, lower volatilityLower return, higher volatilitySNY: 0.5% a year, volatility 25.4%SPY (S&P 500): 12.5% a year, volatility 17.2%ABBV: 25.5% a year, volatility 23.4%AMGN: 20.1% a year, volatility 24.9%NVS: 17.4% a year, volatility 20.7%JNJ: 13.5% a year, volatility 18.0%GILD: 22.8% a year, volatility 24.9%GSK: 9.6% a year, volatility 24.5%BMY: 6.1% a year, volatility 25.0%MRK: 16.2% a year, volatility 24.8%TAK: 12.3% a year, volatility 19.4%PFE: −1.7% a year, volatility 25.4%BIIB: −0.8% a year, volatility 34.8%NVO: −4.3% a year, volatility 39.1%BNTX: −20.1% a year, volatility 52.5%LLY: 41.2% a year, volatility 32.8%TMO: 2.3% a year, volatility 27.8%IQV: 1.6% a year, volatility 34.8%REGN: 7.6% a year, volatility 31.2%AZN: 8.9% a year, volatility 35.7%TEVA: 31.8% a year, volatility 42.8%VTRS: 10.3% a year, volatility 33.6%CVS: 5.0% a year, volatility 30.4%SNYSPY (S&P 500)ABBVAMGNNVSJNJGILDGSKBMYMRKPFEBIIBNVOBNTXLLYTMOIQVREGNAZNTEVAVTRSCVS10.0%20.0%30.0%40.0%50.0%60.0%−40.0%−20.0%0.0%20.0%40.0%60.0%Volatility over 5 years (annualized)Annual return over 5 yearsHigher return, lower volatilityLower return, higher volatilitySNY: 0.5% a year, volatility 25.4%SPY (S&P 500): 12.5% a year, volatility 17.2%ABBV: 25.5% a year, volatility 23.4%AMGN: 20.1% a year, volatility 24.9%NVS: 17.4% a year, volatility 20.7%JNJ: 13.5% a year, volatility 18.0%GILD: 22.8% a year, volatility 24.9%GSK: 9.6% a year, volatility 24.5%BMY: 6.1% a year, volatility 25.0%MRK: 16.2% a year, volatility 24.8%TAK: 12.3% a year, volatility 19.4%PFE: −1.7% a year, volatility 25.4%BIIB: −0.8% a year, volatility 34.8%NVO: −4.3% a year, volatility 39.1%BNTX: −20.1% a year, volatility 52.5%LLY: 41.2% a year, volatility 32.8%TMO: 2.3% a year, volatility 27.8%IQV: 1.6% a year, volatility 34.8%REGN: 7.6% a year, volatility 31.2%AZN: 8.9% a year, volatility 35.7%TEVA: 31.8% a year, volatility 42.8%VTRS: 10.3% a year, volatility 33.6%CVS: 5.0% a year, volatility 30.4%SNYSPY (S&P 500)ABBVAMGNNVSJNJGILDBMYPFEBIIBBNTXLLYREGNTEVA
All figures
InvestmentAnnual returnVolatility
LLY Eli Lilly and Company+41.2%32.8%
TEVA Teva Pharmaceutical Industries Limited+31.8%42.8%
ABBV AbbVie Inc.+25.5%23.4%
GILD Gilead Sciences, Inc.+22.8%24.9%
AMGN Amgen Inc.+20.1%24.9%
NVS Novartis AG+17.4%20.7%
MRK Merck & Co., Inc.+16.2%24.8%
JNJ Johnson & Johnson+13.5%18.0%
SPY S&P 500State Street SPDR S&P 500 ETF+12.5%17.2%
TAK Takeda Pharmaceutical Company Limited+12.3%19.4%
VTRS Viatris Inc.+10.3%33.6%
GSK GSK plc+9.6%24.5%
AZN AstraZeneca PLC+8.9%35.7%
REGN Regeneron Pharmaceuticals, Inc.+7.6%31.2%
BMY Bristol-Myers Squibb Company+6.1%25.0%
CVS CVS Health Corp.+5.0%30.4%
TMO Thermo Fisher Scientific Inc.+2.3%27.8%
IQV IQVIA Holdings Inc.+1.6%34.8%
SNY This pageSanofi+0.5%25.4%
BIIB Biogen Inc.−0.8%34.8%
PFE Pfizer Inc.−1.7%25.4%
NVO Novo Nordisk A/S−4.3%39.1%
BNTX BioNTech SE−20.1%52.5%
Open these 23 in EasyCompare

Has SNY consistently beaten its popular alternatives?

This section compares SNY with the investments people most often weigh against it, checking each one over eight periods from one month to ten years. Counting how often an alternative earned more than SNY helps separate lasting outperformance from a single strong stretch.

A green cell means the alternative earned more than SNY over that period. "Qualified" marks those that did so in at least 3 of 5 short-term periods and 2 of 3 long-term periods.

InvestmentPeriods outperformed Short termLong termRisk · 5 yearsFund
1M3M6MYTD1Y3Y5Y10YVolatilitylower is calmerSharpehigher is betterWorst declinepast 10 yearsExpenseAssetsOverlapsame sectors
SNY Sanofi (this page)—−1.3%−4.2%−7.0%−9.5%−12.7%−8.8%+2.6%+65.1%25.4%0.15−33.5%—$101B—
LLY QualifiedEli Lilly and Company5/5 short3/3 longAll-weather+11.7%+12.5%+42.3%+21.5%+61.9%+131%+461%+1,870%32.8%1.22−34.5%—$1.2T—
ABBV QualifiedAbbVie Inc.5/5 short3/3 longAll-weather+8.1%+13.2%+44.0%+28.0%+28.3%+117%+212%+600%23.4%1.09−45.1%—$503B—
TMO QualifiedThermo Fisher Scientific Inc.5/5 short3/3 longAll-weather+2.7%+28.6%+31.9%+14.5%+19.7%+47.9%+12.1%+355%27.8%0.22−40.9%—$250B—
AMGN QualifiedAmgen Inc.5/5 short3/3 longAll-weather+9.0%+22.9%+31.0%+39.3%+55.3%+79.2%+150%+280%24.9%0.86−24.9%—$242B—
IQV QualifiedIQVIA Holdings Inc.5/5 short3/3 longAll-weather+3.0%+40.2%+58.8%+23.5%+27.8%+51.5%+8.3%+273%34.8%0.22−51.5%—$46B—
NVS QualifiedNovartis AG5/5 short3/3 longAll-weather+10.6%+2.1%+6.1%+15.0%+21.2%+78.9%+123%+234%20.7%0.89−26.8%—$297B—
JNJ QualifiedJohnson & Johnson5/5 short3/3 longAll-weather−0.6%+5.2%+19.6%+31.1%+41.8%+92.5%+88.0%+209%18.0%0.80−27.4%—$645B—
GILD QualifiedGilead Sciences, Inc.5/5 short3/3 longAll-weather+3.0%+21.3%+19.7%+31.6%+32.6%+123%+179%+202%24.9%0.95−30.5%—$195B—
REGN QualifiedRegeneron Pharmaceuticals, Inc.5/5 short3/3 longAll-weather+1.9%+25.9%+10.0%+5.9%+40.8%+3.9%+44.5%+128%31.2%0.39−59.7%—$84B—
GSK QualifiedGSK plc5/5 short3/3 longAll-weather+1.0%+1.8%−6.4%+5.9%+19.8%+60.8%+57.8%+101%24.5%0.50−37.6%—$103B—
BMY QualifiedBristol-Myers Squibb Company5/5 short3/3 longAll-weather+2.3%+4.8%+9.5%+21.6%+48.2%+29.6%+34.5%+82.7%25.0%0.36−47.7%—$129B—
AZN QualifiedAstraZeneca PLC4/5 short3/3 longAll-weather+2.5%+2.3%−10.8%−4.9%+4.1%+46.6%+53.2%+276%35.7%0.42−28.7%—$268B—
MRK QualifiedMerck & Co., Inc.4/5 short3/3 longAll-weather−2.4%+16.2%+32.1%+41.2%+73.0%+56.1%+111%+245%24.8%0.73−43.4%—$363B—
TAK QualifiedTakeda Pharmaceutical Company Limited5/5 short2/3 long+9.8%+23.2%+25.3%+35.5%+49.6%+58.4%+78.4%+33.3%19.4%0.70−54.4%—$64B—
TEVA QualifiedTeva Pharmaceutical Industries Limited5/5 short2/3 long+1.7%+33.4%+28.8%+29.9%+112%+392%+297%−3.6%42.8%0.85−85.3%—$47B—
VTRS QualifiedViatris Inc.5/5 short2/3 long+7.6%+9.5%+29.1%+51.7%+83.7%+135%+63.4%−38.5%33.6%0.47−82.0%—$21B—
CVS QualifiedCVS Health Corp.4/5 short2/3 long+9.3%−11.4%+26.4%+21.5%+19.7%+53.4%+27.6%+46.5%30.4%0.32−56.8%—$121B—
PFE Drug Manufacturers - GeneralPfizer Inc.5/5 short1/3 long+8.9%+24.7%+17.4%+27.0%+31.7%+19.6%−8.2%+58.7%25.4%0.06−58.9%—$173B—
BIIB Drug Manufacturers - GeneralBiogen Inc.5/5 short1/3 long+12.6%+28.4%+33.6%+42.8%+71.8%+0.2%−4.1%−12.7%34.8%0.14−72.7%—$38B—
NVO Drug Manufacturers - GeneralNovo Nordisk A/S2/5 short1/3 long+0.1%−17.4%+2.0%−23.8%−25.2%−57.2%−19.5%+136%39.1%0.09−75.2%—$175B—
BNTX BiotechnologyBioNTech SE2/5 short1/3 long−11.1%−2.4%−17.4%−7.3%−15.6%−3.1%−67.4%—52.5%-0.17−82.3%—$23B—
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How did SNY do year by year?

This table shows each investment's total return in every full calendar year since 2003, along with where SNY ranked among its popular alternatives each year. Annual results reveal how consistently each one kept pace with SNY and how far its good and bad years diverged, detail that multiyear averages tend to smooth over.

Newest year first. Green marks a year in which the fund came out ahead of SNY; gray means the two finished within a fraction of a point. The rank row places SNY among the alternatives that traded the full year; dark green is the top quarter and red the bottom quarter.

InvestmentYears ahead of SNY20252024202320222021202020192018201720162015201420132012201120102009200820072006200520042003
SNY This pageSanofi—+4.9%+1.1%+6.5%+0.5%+7.0%+0.4%+20.5%+6.0%+9.9%−1.2%−3.4%−11.9%+17.1%+36.0%+18.8%−13.4%+28.7%−26.5%+1.0%+7.2%+11.6%+8.2%+26.2%
Rank among alternativesTop quarter in 1 of 2318 of 228 of 229 of 2215 of 2214 of 2212 of 2211 of 2110 of 2114 of 218 of 2116 of 2120 of 2116 of 206 of 198 of 1918 of 195 of 1914 of 1812 of 1814 of 188 of 188 of 1811 of 18
SPY S&P 500State Street SPDR S&P 500 ETF16 of 23+17.7%+24.9%+26.2%−18.2%+28.7%+18.3%+31.2%−4.6%+21.7%+12.0%+1.2%+13.5%+32.3%+16.0%+1.9%+15.1%+26.4%−36.8%+5.1%+15.9%+4.8%+10.7%+28.2%
LLY Eli Lilly and Company14 of 23+40.3%+33.3%+60.9%+34.3%+66.1%+31.0%+16.2%+40.5%+17.8%−10.4%+25.4%+39.8%+7.3%+24.2%+25.2%+3.6%−6.2%−21.3%+5.7%−5.2%+2.6%−17.6%+13.1%
ABBV AbbVie Inc.9 of 13+33.1%+18.9%−0.2%+24.0%+32.4%+27.7%+1.5%−1.0%+60.1%+9.8%−6.5%+27.9%+60.7%——————————
TMO Thermo Fisher Scientific Inc.16 of 23+11.8%−1.7%−3.4%−17.3%+43.5%+43.7%+45.6%+18.2%+35.0%−0.1%+13.8%+13.1%+75.8%+43.2%−18.8%+16.1%+40.0%−40.9%+27.4%+50.3%−0.2%+19.8%+25.3%
AMGN Amgen Inc.13 of 23+29.7%−6.8%+13.5%+20.4%+0.9%−2.0%+27.6%+15.2%+22.3%−7.6%+4.0%+42.3%+34.8%+36.8%+18.2%−3.0%−2.0%+24.3%−32.0%−13.4%+22.9%+3.8%+27.8%
IQV IQVIA Holdings Inc.10 of 12+14.7%−15.1%+12.9%−27.4%+57.5%+16.0%+33.0%+18.7%+28.7%+10.8%+16.6%+27.0%———————————
NVS Novartis AG13 of 23+46.0%−0.5%+21.1%+6.6%−5.0%+2.2%+29.1%+6.2%+19.8%−11.8%−4.3%+19.4%+32.2%+16.1%+1.5%+12.6%+14.6%−5.4%−3.4%+11.3%+6.0%+12.3%+27.5%
JNJ Johnson & Johnson14 of 23+47.5%−4.8%−8.6%+6.0%+11.4%+10.8%+16.2%−5.1%+24.4%+15.3%+1.2%+17.3%+34.6%+10.8%+9.9%−0.6%+11.3%−7.7%+3.6%+12.4%−3.4%+25.2%−2.0%
GILD Gilead Sciences, Inc.14 of 23+36.6%+18.7%−2.0%+23.6%+29.9%−6.7%+7.9%−9.9%+3.0%−27.6%+8.6%+25.5%+105%+79.5%+12.9%−16.3%−15.4%+11.2%+41.7%+23.4%+50.2%+20.1%+71.4%
REGN Regeneron Pharmaceuticals, Inc.16 of 23+9.0%−18.9%+21.7%+14.2%+30.7%+28.7%+0.5%−0.7%+2.4%−32.4%+32.3%+49.0%+60.9%+209%+68.8%+35.8%+31.7%−24.0%+20.3%+26.2%+72.7%−37.4%−20.6%
GSK GSK plc13 of 23+51.3%−5.2%+9.8%−16.8%+27.1%−17.7%+29.2%+13.8%−3.0%+2.1%−0.3%−15.7%+28.9%+0.6%+22.7%−2.1%+19.2%−22.2%−0.8%+7.9%+9.9%+5.6%+28.8%
BMY Bristol-Myers Squibb Company12 of 23+0.1%+15.8%−26.1%+19.0%+2.9%+0.4%+27.7%−12.9%+7.7%−13.5%+19.3%+14.2%+70.0%−3.8%+39.4%+8.8%+14.8%−6.1%+4.8%+19.9%−6.2%−7.2%+29.1%
AZN AstraZeneca PLC15 of 23+38.0%−1.2%+0.8%+20.4%+17.9%+2.9%+37.4%+13.9%+35.3%−16.7%+0.1%+24.6%+32.0%+8.6%+6.0%+3.5%+20.4%+0.3%−17.1%+12.7%+36.9%−22.0%+38.2%
MRK Merck & Co., Inc.10 of 23+9.8%−6.3%+1.0%+49.4%+1.8%−7.2%+22.3%+40.0%−1.5%+15.0%−3.9%+16.9%+26.9%+13.1%+9.6%+2.9%+26.7%−45.3%+37.3%+42.8%+4.0%−27.7%−11.2%
TAK Takeda Pharmaceutical Company Limited7 of 17+22.7%−3.2%−4.8%+20.1%−21.6%−3.0%+22.1%−38.8%+41.3%−14.0%+24.4%−6.5%+7.4%+5.8%−5.0%+21.2%−16.1%——————
TEVA Teva Pharmaceutical Industries Limited12 of 23+41.6%+111%+14.5%+13.9%−17.0%−1.5%−36.4%−18.6%−46.0%−43.2%+16.7%+47.4%+10.9%−5.1%−21.0%−5.9%+33.6%−7.4%+50.9%−27.1%+45.2%+6.1%+47.8%
VTRS Viatris Inc.8 of 23+5.0%+19.7%+2.0%−14.3%−26.2%−6.8%−26.6%−35.2%+10.9%−29.4%−4.1%+29.9%+58.1%+27.9%+1.6%+14.6%+86.4%−29.7%−29.1%+1.1%+14.2%−29.6%+63.5%
CVS CVS Health Corp.11 of 23+84.3%−40.8%−12.5%−7.6%+54.9%−5.1%+17.3%−7.0%−5.8%−17.8%+2.9%+36.6%+50.4%+20.3%+18.9%+9.1%+13.2%−27.2%+29.4%+17.6%+17.8%+25.7%+45.9%
PFE Pfizer Inc.12 of 23+0.6%−2.2%−41.3%−10.4%+66.7%+3.4%−6.7%+25.1%+16.1%+4.4%+7.3%+5.4%+26.5%+20.6%+28.8%+0.6%+8.1%−16.9%−8.2%+15.3%−10.6%−22.3%+17.7%
BIIB Biogen Inc.11 of 23+15.1%−40.9%−6.6%+15.4%−2.0%−17.5%−1.4%−5.5%+12.3%−7.4%−9.8%+21.4%+91.0%+33.0%+64.1%+25.3%+12.3%−16.3%+15.7%+8.6%−32.0%+81.5%+10.6%
NVO Novo Nordisk A/S15 of 23−39.2%−15.9%+54.8%+22.6%+63.5%+23.3%+28.7%−11.8%+54.3%−36.6%+39.3%+16.7%+15.3%+44.0%+4.1%+79.3%+27.2%−19.8%+57.4%+51.3%+5.6%+34.6%+43.5%
BNTX BioNTech SE3 of 6−16.4%+8.0%−29.7%−41.0%+216%+141%—————————————————
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Risk and diversification

How SNY has fallen, how it held up in crashes beside the S&P 500 and its popular alternatives, and what moves independently of it.

What were SNY's worst declines?

A drawdown is the decline from a peak to the lowest point before a new high. This section presents SNY's five deepest drawdowns since it began trading in 2002, alongside the S&P 500's return over the same dates, and how long each took to recover. Together, these figures show how much an investor could have lost and how long it took to get back to even.

Green means SNY fell less than the S&P 500 over the same dates. Based on daily closing prices with dividends reinvested.

DuringSNY fellS&P 500, same datesPeakLowTime to the lowBack at the peakTime to recover
2008 financial crisis−46.7%−42.8%Jul 2006Mar 20092.7 yearsJul 20112.3 years
2022 bear market−33.5%−7.0%May 2022Sep 20224 monthsApr 20237 months
2015 China and oil sell-off−30.8%−5.8%Sep 2014Feb 201617 monthsOct 20193.7 years
Dot-com bust−29.0%−8.9%Aug 2002Feb 20036 monthsMay 20033 months
No named crash−28.5%+38.5%Mar 2025Oct 202619 monthsNot yet—

How did SNY do in stock market crashes?

This section measures how far SNY, the S&P 500 and each alternative fell from peak to trough during every major market crash since 2000. A smaller decline means an investment held up better, and comparing results across crashes shows whether that resilience was consistent or a one-off.

Note: SNY began trading on July 1, 2002, so its row reads "Not yet trading" for the dot-com bust. The older alternatives and the S&P 500 show how those crashes played out.

Newest crash first. Each figure is the fund's deepest fall within the crash window; green means a smaller fall than SNY.

InvestmentHeld up better2023 regional bank crisisMar 20232022 bear marketJan 2022Covid crashFeb 2020Late-2018 sell-offSep 2018February 2018 volatility shockFeb 20182015 China and oil sell-offAug 20152011 euro debt crisisJul 20112010 flash crashMay 20102008 financial crisisOct 2007Dot-com bustMar 2000
SNY This pageSanofi—−0.5%−33.5%−25.2%−9.0%−9.8%−30.2%−20.7%−2.8%−46.6%Not yet trading
SPY S&P 500State Street SPDR S&P 500 ETF5 of 9−3.4%−24.5%−33.7%−19.3%−6.5%−12.8%−17.9%−1.5%−55.2%−47.5%
LLY Eli Lilly and Company6 of 9−0.6%−11.7%−16.9%−10.2%−8.6%−19.6%−10.9%0.0%−50.0%−54.3%
ABBV AbbVie Inc.2 of 6−1.5%−21.9%−32.1%−18.1%−5.8%−29.8%————
TMO Thermo Fisher Scientific Inc.3 of 9−2.4%−19.8%−24.8%−17.2%−8.7%−14.7%−24.4%−3.6%−53.9%−41.8%
AMGN Amgen Inc.7 of 9−1.2%−11.9%−18.3%−14.3%−7.4%−22.1%−12.6%−0.5%−31.3%−60.2%
IQV IQVIA Holdings Inc.2 of 6−6.8%−35.9%−48.9%−19.2%−5.3%−28.7%————
NVS Novartis AG4 of 9−1.1%−20.4%−25.5%−9.9%−6.6%−30.1%−14.5%−2.6%−41.7%−25.7%
JNJ Johnson & Johnson6 of 9−1.1%−12.7%−25.4%−16.9%−8.2%−9.0%−9.8%−0.1%−34.4%−35.9%
GILD Gilead Sciences, Inc.7 of 9−1.6%−20.0%−13.7%−22.7%−5.5%−28.7%−18.2%−2.1%−34.3%−53.6%
REGN Regeneron Pharmaceuticals, Inc.3 of 9−0.2%−25.8%−12.7%−17.3%−7.3%−37.7%−23.2%−7.2%−49.9%−71.6%
GSK GSK plc4 of 9−0.3%−37.6%−26.5%−11.5%−4.3%−15.7%−12.4%−2.0%−46.6%−45.1%
BMY Bristol-Myers Squibb Company6 of 9−2.3%−16.0%−29.4%−22.9%−4.1%−16.3%−10.5%0.0%−39.2%−69.5%
AZN AstraZeneca PLC7 of 9−0.5%−25.7%−22.6%−11.4%−6.4%−18.0%−16.4%−1.1%−37.4%−43.5%
MRK Merck & Co., Inc.5 of 9−2.4%−10.8%−19.3%−9.7%−6.6%−18.2%−17.4%−2.3%−63.3%−57.5%
TAK Takeda Pharmaceutical Company Limited4 of 8−0.6%−14.8%−31.5%−27.9%−6.5%−17.0%−5.6%−3.7%——
TEVA Teva Pharmaceutical Industries Limited2 of 9−7.4%−34.0%−50.3%−40.1%−10.7%−21.8%−25.8%−2.4%−23.5%−34.7%
VTRS Viatris Inc.2 of 9−6.9%−43.3%−37.3%−32.8%−6.8%−31.9%−32.4%−0.1%−64.4%−47.3%
CVS CVS Health Corp.6 of 9−4.4%−19.9%−27.3%−22.1%−9.2%−16.9%−14.2%−1.1%−45.3%−62.4%
PFE Pfizer Inc.6 of 9−1.8%−24.6%−21.8%−12.3%−8.1%−18.2%−16.1%−1.8%−49.8%−46.0%
BIIB Biogen Inc.5 of 9−2.5%−22.4%−21.2%−21.7%−9.3%−24.6%−19.4%−0.6%−52.7%−59.8%
NVO Novo Nordisk A/S6 of 9−1.1%−21.4%−23.7%−13.8%−3.9%−20.8%−23.1%−1.7%−40.9%−51.0%
BNTX BioNTech SE0 of 3−1.2%−45.7%−49.5%———————
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How closely does SNY move with the S&P 500?

Upside capture measures how much of the S&P 500's gains an investment kept in the months the market rose, and downside capture how much of its losses it took in the months the market fell. An investment that captures more of the gains than the losses has compounded ahead of the market over time. This section compares SNY with its popular alternatives on both measures, and on beta (how strongly each has moved with the market), over the past 10 years.

Monthly total returns over the past 10 years, measured against SPY. 100% capture or a beta of 1.00 means moving in line with the S&P 500. Green marks a better figure than SNY's: more upside, less downside or a higher capture ratio. Sorted by capture ratio.

InvestmentUpside captureDownside captureCapture ratioBeta
SNY This pageSanofi53%74%0.720.46
LLY Eli Lilly and Company101%6%15.730.37
ABBV AbbVie Inc.92%57%1.620.54
AZN AstraZeneca PLC60%39%1.520.39
GILD Gilead Sciences, Inc.52%36%1.440.35
MRK Merck & Co., Inc.64%46%1.390.30
JNJ Johnson & Johnson64%53%1.200.46
AMGN Amgen Inc.74%64%1.160.54
NVS Novartis AG69%64%1.080.49
TMO Thermo Fisher Scientific Inc.104%104%1.000.81
REGN Regeneron Pharmaceuticals, Inc.55%66%0.840.19
GSK GSK plc51%61%0.820.52
NVO Novo Nordisk A/S75%94%0.800.60
IQV IQVIA Holdings Inc.128%167%0.771.31
BMY Bristol-Myers Squibb Company55%75%0.730.41
PFE Pfizer Inc.52%81%0.650.54
CVS CVS Health Corp.59%99%0.600.70
TAK Takeda Pharmaceutical Company Limited34%58%0.580.44
TEVA Teva Pharmaceutical Industries Limited55%116%0.481.11
VTRS Viatris Inc.74%179%0.411.14
BIIB Biogen Inc.35%91%0.380.28
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What diversifies SNY?

Correlation measures how closely two investments move together, on a scale from 1 (in lockstep) through 0 (unrelated) to -1 (in opposite directions). This section lists large ETFs and stocks whose returns have had a low correlation with SNY's. Because such investments tend not to fall at the same time, pairing SNY with them can reduce a portfolio's overall swings.

Only ETFs with at least $1.0B in assets and stocks worth at least $10B, with a correlation below 0.5 over the past 5 years and a positive return, are included, ranked by Sharpe ratio; funds that hold the same thing are shown once. The year columns are the years in which SNY lost money. The last two columns show a portfolio that is 80% SNY and 20% the other investment, rebalanced monthly.

ETFs

InvestmentCorrelation5Y returnSharpe2016201520142010200880/20 mix volatility80/20 mix annual return
SNY Sanofi (this page)1.00+2.6%0.15−1.2%−3.4%−11.9%−13.4%−26.5%21.2%+0.9%
LVHI InternationalFranklin International Low Volatility High Dividend Index ETF0.43+119%1.48—————17.8%+4.2%
DXJ InternationalWisdomTree Japan Hedged Equity Fund0.12+225%1.34+1.1%+7.7%+8.1%−1.8%−20.8%17.4%+6.1%
EMLP Broad MarketFirst Trust North American Energy Infrastructure Fund0.26+103%1.06+29.8%−25.3%+23.8%——17.9%+4.0%
HDV Dividend & IncomeiShares Core High Dividend ETF0.49+86.8%1.03+15.8%−0.3%+12.6%——18.5%+3.3%
DBEF InternationalXtrackers MSCI EAFE Hedged Equity ETF0.39+83.6%0.95+6.3%+4.1%+3.4%——17.9%+3.6%
SMH TechnologyVanEck Semiconductor ETF0.06+304%0.94+35.6%−0.3%+30.2%+19.0%−44.7%18.7%+8.6%
XLE EnergyState Street Energy Select Sector SPDR ETF0.32+178%0.94+28.0%−21.5%−8.7%+21.9%−39.0%19.2%+5.6%
GLD CommoditiesSPDR Gold Shares0.25+120%0.93+8.0%−10.7%−2.2%+29.3%+4.9%18.1%+4.6%

Stocks

InvestmentCorrelation5Y returnSharpe2016201520142010200880/20 mix volatility80/20 mix annual return
SNY Sanofi (this page)1.00+2.6%0.15−1.2%−3.4%−11.9%−13.4%−26.5%21.2%+0.9%
CAH Medical - DistributionCardinal Health, Inc.0.04+471%1.54−17.5%+12.6%+23.0%+21.4%−39.6%18.0%+8.3%
CLS Hardware, Equipment & PartsCelestica Inc.0.02+2,780%1.43+7.4%−6.0%+12.9%+2.8%−20.5%20.8%+20.3%
MCK Medical - DistributionMcKesson Corporation0.06+397%1.41−28.3%−4.5%+29.3%+13.8%−40.4%17.9%+7.8%
FIX Engineering & ConstructionComfort Systems USA, Inc.-0.06+1,452%1.41+18.3%+67.7%−10.4%+8.7%−15.2%18.7%+16.7%
MPC Oil & Gas Refining & MarketingMarathon Petroleum Corporation0.18+660%1.39+0.7%+17.4%+0.4%——19.2%+10.1%
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Common questions

What was SNY's worst drawdown?

SNY's deepest decline since it began trading in 2002 was 46.7%, from July 2006 to March 2009. It took 28 months from the low to climb back to its old high.

What were SNY's best and worst years?

Over 23 full calendar years, SNY's best year was 2012, when it returned 36.0%. Its worst was 2008, with a return of -26.5%.

Is there a better investment than SNY?

Among SNY's popular alternatives, JNJ, NVS and ABBV earned more than SNY with less volatility over the past 5 years. JNJ returned 13.5% a year at 18.0% volatility, against 0.5% a year at 25.4%. Looking beyond its popular alternatives, RPRX (pharmaceuticals) and IBB (biotechnology) earned more than SNY with less volatility over the past 5 years. RPRX returned 13.8% a year at 23.8% volatility, against 0.5% a year at 25.4%.

Is SNY more volatile than the S&P 500?

Yes. SNY's volatility over the past 5 years was 25.4%, 1.5 times the S&P 500's 17.2%. Volatility measures how widely returns swing around their average: in roughly two years out of three, SNY's return lands within 25.4% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump.

What is SNY's Sharpe ratio?

SNY's Sharpe ratio over the past 5 years was 0.15, against 0.78 for the S&P 500, so SNY earned less for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings.

How correlated is SNY with the S&P 500?

Over the past 5 years, SNY's monthly returns had a correlation of 0.25 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They are only loosely linked, which makes it a real diversifier next to an index fund. In the table, the correlation column measures each option against SNY instead: the lower it is, the more that option would diversify a SNY holding.

What are the best alternatives to SNY?

Of the 21 popular alternatives we compared, 17 outperformed SNY in at least 3 of 5 short-term and 2 of 3 long-term timeframes, with dividends reinvested: LLY, ABBV and TMO.

Did SNY outperform the S&P 500?

SNY finished ahead of the S&P 500 (SPY) in seven of 23 full calendar years. In 2025, it returned +4.9%, against +17.7% for the index.

How did SNY do in stock market crashes?

SNY fell less than the S&P 500 (SPY) in four of the nine major crashes it has traded through, and further in five. The clearest case was the 2015 China and oil sell-off, when SNY fell 30.2% and the S&P 500 fell 12.8%.

What diversifies SNY?

These had a low correlation with SNY over the past 5 years and still earned a positive 5-year return: among large ETFs, LVHI (correlation 0.43), DXJ (correlation 0.12) and EMLP (correlation 0.26); among large stocks, CAH (correlation 0.04), CLS (correlation 0.02) and MCK (correlation 0.06). A correlation near zero means the two have moved largely independently.

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