BetterThanSPY

Relative Intelligence · Molecular Diagnostics

How Natera (NTRA) compares with the whole market and its popular alternatives

Built by QuantCommons' quantitative engine, this page is about relative opportunity, not data on NTRA alone. It places NTRA (Natera, Inc.) against 17 popular alternatives, its neighboring categories and the entire market of over 10,000 U.S.-listed stocks and ETFs, and surfaces what has done better on consistent outperformance, return for the risk taken, behavior in real market crashes and diversification. The result is a clearer view of where NTRA stands in the market, and of the alternatives worth a closer look.

Period covered: NTRA's full trading record, from July 2015 through September 2026. The crash tests reach back to 2000 using older funds and the S&P 500. All returns include reinvested dividends. Data as of October 22, 2026.

Data as of October 22, 2026. Full tables and charts read best on a larger screen.

Rank the market against NTRA →Chart NTRA vs. 17 alternatives →

This page answers the following questions about NTRA

Key findings

Not AI-generated

These key findings are generated by our proprietary relative intelligence engine, directly from the data on this page.

How much would $10,000 in NTRA have grown?

This chart tracks a hypothetical $10,000 investment in NTRA over the past 11 years, with dividends reinvested, alongside the same amount in the S&P 500, investments that ended ahead of NTRA over the same span and NTRA's popular alternatives, among those that traded for the entire period. A second view covers the past 5 years, the period the better options further down the page are judged on. It shows not only where each investment ended up but also how smooth or uneven the path was.

Note: NTRA began trading on July 1, 2015, so the chart cannot reach back to the dot-com bust, the 2008 financial crisis or two other sell-offs. It covers the most recent 11 years of NTRA's record, starting at the end of September 2015.

Choose a period

From the end of September 2015 to the end of September 2026. The scale is logarithmic, so equal steps up the chart are equal percentage gains. Hover over a fund in the key to pick out its line. 25 of the 2,594 stocks and funds worth at least $500 million that traded the whole period ended ahead of NTRA; the chart shows 5, closest alternatives first. The other 3 lines are popular alternatives, shown for context.

$10,000$100,000$1M201520172019202120232025$10,000$100,000$1M2015201820212024
  • NVDA$4M+38,276% total · +71.8% a year
  • STRL$1M+11,865% total · +54.5% a year
  • MU$728,938+7,189% total · +47.7% a year
  • FIX$650,440+6,404% total · +46.2% a year
  • ANET$532,964+5,230% total · +43.5% a year
  • NTRA$380,944+3,709% total · +39.2% a year
  • CDNA$155,884+1,459% total · +28.4% a year
  • VCYT$98,172+882% total · +23.1% a year
  • SPY (S&P 500)$47,605+376% total · +15.2% a year
  • ILMN$16,017+60.2% total · +4.4% a year
Change the dates or add tickers to this chart in EasyCompare

From the end of September 2021 to the end of September 2026. The scale is logarithmic, so equal steps up the chart are equal percentage gains. Hover over a fund in the key to pick out its line. 230 of the 3,630 stocks and funds worth at least $500 million that traded the whole period ended ahead of NTRA; the chart shows 5, closest alternatives first. The other 3 lines are popular alternatives, shown for context.

$1,000$10,000$100,000202120222023202420252026$1,000$10,000$100,000202120222023202420252026
  • FIX$236,701+2,267% total · +88.3% a year
  • MU$153,675+1,437% total · +72.7% a year
  • PBR-A$67,821+578% total · +46.6% a year
  • SMH$48,982+390% total · +37.4% a year
  • UFPT$48,192+382% total · +37.0% a year
  • NTRA$37,089+271% total · +30.0% a year
  • SPY (S&P 500)$19,000+90.0% total · +13.7% a year
  • CDNA$10,257+2.6% total · +0.5% a year
  • PSNL$8,462−15.4% total · −3.3% a year
  • ILMN$6,943−30.6% total · −7.0% a year
Change the dates or add tickers to this chart in EasyCompare

NTRA at a glance

This section summarizes the key facts about the stock, its returns over periods from one to ten years and the risk it has carried, with dividends reinvested throughout. These figures serve as the baseline for every comparison that follows.

Note: NTRA began trading on July 1, 2015, so every figure here, including its worst decline, covers only the time since then. None of them reflect the dot-com bust, the 2008 financial crisis or two other sell-offs.

The company

Market value
$58B
Industry
Medical - Diagnostics & Research
Price history from
July 2015

Returns

Past 1 year
+113%total return
Past 3 years
+901%+116% a year
Past 5 years
+249%+28.4% a year
Past 10 years
+3,934%+44.7% a year
Best calendar year
+195%2020
Worst calendar year
−57.0%2022
Losing years
3 of 10full calendar years

Risk

Volatility
57.6%typical yearly swing, 5 years
Sharpe ratio
0.73return per unit of risk, 5 years
Worst decline ever
−77.7%Sep 2021 to May 2022
From its all-time high
−5.7%below the peak

NTRA against the whole market

Where NTRA ranks among every stock and fund, and what across the market has done better.

How does NTRA rank among all stocks?

This section ranks NTRA on return, volatility, risk-adjusted return and worst decline against every stock worth at least $300 million with enough history. Where the comparisons with its popular alternatives show how NTRA stacks up against its peers, these rankings show where it stands in the market as a whole.

Ranked against U.S.-listed stocks worth at least $300M that have enough history for each measure, so the count changes from row to row; smaller stocks are left out. Lower volatility and smaller declines rank higher.

MeasureNTRARankStanding
1-year return+113%135 of 3,282top 4%
3-year return+901%34 of 3,016top 1%
5-year return+249%221 of 2,897top 8%
10-year return+3,934%9 of 2,201top 1%
Volatility, 5 years57.6%2,205 of 2,897bottom 25%
Sharpe ratio, 5 years0.73401 of 2,897top 14%
Worst decline, past 10 years−77.7%1,552 of 2,184bottom 30%

What has beaten NTRA on both return and risk?

Each dot is an investment, placed by how much it earned a year over the past 5 years (higher is better) and how much its price swung, its volatility (further left is calmer). NTRA sits where the dashed lines cross. Anything in the green box above and to the left earned more than NTRA with smaller swings, a better trade-off over this period on both counts. Past results are no promise, but a name in the box is worth a closer look.

Annual return is the annualized total return with dividends reinvested, and volatility the annualized swing in daily prices, both over 5 years. Labeled dots are the strongest picks from the table below and the names called out above, colored by how close they sit to NTRA; faint dots are 95 more of the 130 in the green region (the strongest, one per fund family). 3,641 stocks and funds worth at least $500 million were screened. Hover over a dot for its figures.

10.0%20.0%30.0%40.0%50.0%60.0%70.0%0.0%10.0%20.0%30.0%40.0%50.0%60.0%70.0%80.0%Volatility over 5 years (annualized)Annual return over 5 yearsMore return, less volatility than NTRANVDA: +56.5% a year, volatility 51.9%CAH: +41.7% a year, volatility 24.7%HWM: +45.1% a year, volatility 32.7%TSM: +31.0% a year, volatility 38.6%AVGO: +46.9% a year, volatility 44.6%LLY: +41.2% a year, volatility 32.8%HSBC: +32.8% a year, volatility 25.9%CAT: +30.7% a year, volatility 32.0%DELL: +53.8% a year, volatility 54.5%MUFG: +33.5% a year, volatility 29.4%INSW: +58.7% a year, volatility 40.6%PANW: +33.4% a year, volatility 43.4%MCK: +37.8% a year, volatility 25.1%ANET: +47.6% a year, volatility 49.1%LRCX: +34.2% a year, volatility 50.1%APH: +31.3% a year, volatility 32.4%BBVA: +39.0% a year, volatility 33.3%STX: +53.4% a year, volatility 48.8%VLO: +43.8% a year, volatility 36.9%KLAC: +35.3% a year, volatility 46.9%IBKR: +35.3% a year, volatility 35.5%WDC: +52.5% a year, volatility 53.6%MFG: +33.9% a year, volatility 30.6%SCCO: +30.1% a year, volatility 40.8%PSX: +32.7% a year, volatility 32.9%SMFG: +34.0% a year, volatility 29.4%ASX: +47.3% a year, volatility 43.3%PWR: +36.4% a year, volatility 37.4%GLW: +29.7% a year, volatility 42.2%HPE: +32.8% a year, volatility 42.3%VST: +51.7% a year, volatility 48.8%ESLT: +39.7% a year, volatility 34.6%CIEN: +43.7% a year, volatility 52.9%EME: +40.8% a year, volatility 35.4%AU: +38.0% a year, volatility 50.0%STLD: +32.4% a year, volatility 38.0%BAP: +29.7% a year, volatility 30.3%CASY: +30.8% a year, volatility 29.4%SBS: +40.9% a year, volatility 36.9%JBL: +34.5% a year, volatility 39.7%CIB: +33.5% a year, volatility 32.9%KGC: +31.4% a year, volatility 45.6%CW: +29.5% a year, volatility 28.8%NVT: +32.5% a year, volatility 38.5%COKE: +41.6% a year, volatility 38.0%THC: +30.8% a year, volatility 45.0%TSEM: +40.1% a year, volatility 52.4%MLI: +36.5% a year, volatility 33.4%FRO: +53.9% a year, volatility 49.7%MOG-A: +35.1% a year, volatility 32.1%AGI: +31.5% a year, volatility 42.4%IDCC: +39.4% a year, volatility 36.9%JXN: +42.4% a year, volatility 43.3%MPC: +50.0% a year, volatility 33.4%LAUR: +36.9% a year, volatility 32.8%SNEX: +32.5% a year, volatility 37.3%TRMD: +54.8% a year, volatility 46.0%BWLP: +60.5% a year, volatility 50.9%AGX: +52.0% a year, volatility 54.1%MIRM: +40.4% a year, volatility 51.7%NHC: +31.2% a year, volatility 28.6%DHT: +40.3% a year, volatility 39.0%TNK: +52.2% a year, volatility 45.1%GFF: +36.9% a year, volatility 41.7%TRGP: +41.8% a year, volatility 31.7%USLM: +36.8% a year, volatility 36.1%LPG: +55.8% a year, volatility 43.6%HURN: +31.3% a year, volatility 40.8%HWKN: +29.8% a year, volatility 36.6%BLX: +31.0% a year, volatility 25.9%TEN: +48.0% a year, volatility 46.4%ESQ: +32.1% a year, volatility 31.8%PLPC: +38.3% a year, volatility 48.5%ATI: +58.9% a year, volatility 43.2%IGIC: +30.6% a year, volatility 30.9%ODC: +36.9% a year, volatility 36.9%NBN: +29.7% a year, volatility 33.3%NWPX: +32.7% a year, volatility 36.3%ASC: +43.5% a year, volatility 44.7%CLMB: +38.4% a year, volatility 45.5%GE: +36.0% a year, volatility 31.0%PBR: +52.4% a year, volatility 37.4%SAN: +31.7% a year, volatility 33.9%SU: +33.1% a year, volatility 32.5%IMO: +33.7% a year, volatility 32.0%FTI: +54.6% a year, volatility 41.2%TEVA: +31.7% a year, volatility 42.8%YPF: +61.5% a year, volatility 54.1%GFI: +34.0% a year, volatility 53.5%FLEX: +32.7% a year, volatility 48.5%CRS: +57.4% a year, volatility 47.4%DINO: +31.8% a year, volatility 38.8%UNM: +31.4% a year, volatility 29.3%XPO: +30.0% a year, volatility 47.0%PR: +31.5% a year, volatility 47.0%NTRA: +28.4% a year, volatility 57.6%SPY (S&P 500): +12.5% a year, volatility 17.2%UFPT: +36.5% a year, volatility 46.0%GKOS: +31.5% a year, volatility 48.9%FIX: +73.0% a year, volatility 46.9%PBR-A: +53.5% a year, volatility 37.4%MU: +67.0% a year, volatility 57.1%SMH: +32.2% a year, volatility 37.0%STRL: +74.9% a year, volatility 60.2%XOM: +27.5% a year, volatility 26.5%DXJ: +26.6% a year, volatility 19.1%ETON: +55.5% a year, volatility 66.1%BELFB: +75.9% a year, volatility 52.3%NTRASPY (S&P 500)UFPTGKOSFIXPBR-AMUSMHSTRLXOMDXJETONBELFB0.0%20.0%40.0%60.0%80.0%0.0%20.0%40.0%60.0%80.0%Volatility over 5 years (annualized)Annual return over 5 yearsMore return, less volatility than NTRANVDA: +56.5% a year, volatility 51.9%CAH: +41.7% a year, volatility 24.7%HWM: +45.1% a year, volatility 32.7%TSM: +31.0% a year, volatility 38.6%AVGO: +46.9% a year, volatility 44.6%LLY: +41.2% a year, volatility 32.8%HSBC: +32.8% a year, volatility 25.9%CAT: +30.7% a year, volatility 32.0%DELL: +53.8% a year, volatility 54.5%MUFG: +33.5% a year, volatility 29.4%INSW: +58.7% a year, volatility 40.6%PANW: +33.4% a year, volatility 43.4%MCK: +37.8% a year, volatility 25.1%ANET: +47.6% a year, volatility 49.1%LRCX: +34.2% a year, volatility 50.1%APH: +31.3% a year, volatility 32.4%BBVA: +39.0% a year, volatility 33.3%STX: +53.4% a year, volatility 48.8%VLO: +43.8% a year, volatility 36.9%KLAC: +35.3% a year, volatility 46.9%IBKR: +35.3% a year, volatility 35.5%WDC: +52.5% a year, volatility 53.6%MFG: +33.9% a year, volatility 30.6%SCCO: +30.1% a year, volatility 40.8%PSX: +32.7% a year, volatility 32.9%SMFG: +34.0% a year, volatility 29.4%ASX: +47.3% a year, volatility 43.3%PWR: +36.4% a year, volatility 37.4%GLW: +29.7% a year, volatility 42.2%HPE: +32.8% a year, volatility 42.3%VST: +51.7% a year, volatility 48.8%ESLT: +39.7% a year, volatility 34.6%CIEN: +43.7% a year, volatility 52.9%EME: +40.8% a year, volatility 35.4%AU: +38.0% a year, volatility 50.0%STLD: +32.4% a year, volatility 38.0%BAP: +29.7% a year, volatility 30.3%CASY: +30.8% a year, volatility 29.4%SBS: +40.9% a year, volatility 36.9%JBL: +34.5% a year, volatility 39.7%CIB: +33.5% a year, volatility 32.9%KGC: +31.4% a year, volatility 45.6%CW: +29.5% a year, volatility 28.8%NVT: +32.5% a year, volatility 38.5%COKE: +41.6% a year, volatility 38.0%THC: +30.8% a year, volatility 45.0%TSEM: +40.1% a year, volatility 52.4%MLI: +36.5% a year, volatility 33.4%FRO: +53.9% a year, volatility 49.7%MOG-A: +35.1% a year, volatility 32.1%AGI: +31.5% a year, volatility 42.4%IDCC: +39.4% a year, volatility 36.9%JXN: +42.4% a year, volatility 43.3%MPC: +50.0% a year, volatility 33.4%LAUR: +36.9% a year, volatility 32.8%SNEX: +32.5% a year, volatility 37.3%TRMD: +54.8% a year, volatility 46.0%BWLP: +60.5% a year, volatility 50.9%AGX: +52.0% a year, volatility 54.1%MIRM: +40.4% a year, volatility 51.7%NHC: +31.2% a year, volatility 28.6%DHT: +40.3% a year, volatility 39.0%TNK: +52.2% a year, volatility 45.1%GFF: +36.9% a year, volatility 41.7%TRGP: +41.8% a year, volatility 31.7%USLM: +36.8% a year, volatility 36.1%LPG: +55.8% a year, volatility 43.6%HURN: +31.3% a year, volatility 40.8%HWKN: +29.8% a year, volatility 36.6%BLX: +31.0% a year, volatility 25.9%TEN: +48.0% a year, volatility 46.4%ESQ: +32.1% a year, volatility 31.8%PLPC: +38.3% a year, volatility 48.5%ATI: +58.9% a year, volatility 43.2%IGIC: +30.6% a year, volatility 30.9%ODC: +36.9% a year, volatility 36.9%NBN: +29.7% a year, volatility 33.3%NWPX: +32.7% a year, volatility 36.3%ASC: +43.5% a year, volatility 44.7%CLMB: +38.4% a year, volatility 45.5%GE: +36.0% a year, volatility 31.0%PBR: +52.4% a year, volatility 37.4%SAN: +31.7% a year, volatility 33.9%SU: +33.1% a year, volatility 32.5%IMO: +33.7% a year, volatility 32.0%FTI: +54.6% a year, volatility 41.2%TEVA: +31.7% a year, volatility 42.8%YPF: +61.5% a year, volatility 54.1%GFI: +34.0% a year, volatility 53.5%FLEX: +32.7% a year, volatility 48.5%CRS: +57.4% a year, volatility 47.4%DINO: +31.8% a year, volatility 38.8%UNM: +31.4% a year, volatility 29.3%XPO: +30.0% a year, volatility 47.0%PR: +31.5% a year, volatility 47.0%NTRA: +28.4% a year, volatility 57.6%SPY (S&P 500): +12.5% a year, volatility 17.2%UFPT: +36.5% a year, volatility 46.0%GKOS: +31.5% a year, volatility 48.9%FIX: +73.0% a year, volatility 46.9%PBR-A: +53.5% a year, volatility 37.4%MU: +67.0% a year, volatility 57.1%SMH: +32.2% a year, volatility 37.0%STRL: +74.9% a year, volatility 60.2%XOM: +27.5% a year, volatility 26.5%DXJ: +26.6% a year, volatility 19.1%ETON: +55.5% a year, volatility 66.1%BELFB: +75.9% a year, volatility 52.3%NTRASPY (S&P 500)UFPTGKOSFIXPBR-AMUSMHSTRLXOMDXJETON
  • Same and neighboring categories, and shared themes
  • The whole market
  • Others in the green region

Is there a better investment than NTRA?

Investments that beat NTRA over the past 5 years on return, volatility, drawdowns, consistency, crash losses or fees, from its popular alternatives out to the whole market.

How this works

The table below lists investments that beat NTRA over the past 5 years on at least one of these measures: a higher annual return with lower volatility, a higher annual return at similar volatility, a similar return with lower volatility, a higher Sharpe ratio with a smaller worst decline, a higher total return in most periods from 3 months to 10 years, or smaller losses in recent market crashes. It checks NTRA's popular alternatives first, then the rest of its own and neighboring categories, then every stock and fund worth at least $500 million, and shows the strongest few in each group. The full list of those with a higher return and lower volatility than NTRA follows the table.

Annual return is the annualized total return with dividends reinvested. Annual return, volatility and the Sharpe ratio cover 5 years; the worst decline covers the past 10 years. Green marks a better figure than NTRA's. "On the frontier" means no other option shown or tested earned more with less volatility. Funds that hold the same thing are shown once. Beyond the popular alternatives, nothing with more than 1.5× NTRA's volatility counts as better.

These figures cover the past 5 years. Green marks a better figure than NTRA's.

Screen the whole market against NTRA for any period in BetterThanSPYOpen these 11 in EasyCompare
InvestmentWhy it is betterPast 5 yearsDownsideLong runFit
Annual return?higher is betterVolatility?lower is calmerSharpe?return per unit of riskWorst decline?past 10 years10Y returntotalCorr. with NTRA?lower diversifies moreExpenseper year
NTRANatera, Inc. · this page
+28.4%57.6%0.73−77.7%+3,934%1.00—
SPYState Street SPDR S&P 500 ETF · S&P 500
+12.5%17.2%0.78−33.7%+316%0.420.09%
Same and neighboring categories, and shared themesbest 2 shownEverything else in Molecular Diagnostics and Medical Diagnostics and the categories next to it (Life Sciences Tools, Medical Devices), plus NTRA's specific themes. 2 of 103 passed at least one test.
UFPTUFP Technologies, Inc. · Medical Devices
Higher return, lower volatilityHigher Sharpe, smaller worst decline+36.5%46.0%0.91−48.3%+1,009%0.33—
GKOSGlaukos Corporation · Medical Devices
Higher return, lower volatility+31.5%48.9%0.80−69.6%+390%0.24—
The whole marketbest 8 shownEvery other stock and fund worth at least $500 million. 189 of 3,542 passed at least one test.
FIXComfort Systems USA, Inc. · Engineering & Construction
On the frontierHigher return, lower volatilityHigher Sharpe, smaller worst declineSmaller losses in recent crashes+73.0%46.9%1.41−49.7%+4,888%0.33—
PBR-APetróleo Brasileiro S.A. - Petrobras · Integrated Oil & Gas
On the frontierHigher return, lower volatilityHigher Sharpe, smaller worst decline+53.5%37.4%1.34−71.7%+733%-0.02—
MUMicron Technology, Inc. · Semiconductors
Higher return, similar volatilityHigher Sharpe, smaller worst declineSmaller losses in recent crashes+67.0%57.1%1.19−57.6%+5,050%0.25—
SMHVanEck Semiconductor ETF · Semiconductors
Higher return, lower volatilityHigher Sharpe, smaller worst decline+32.2%37.0%0.94−45.3%+1,570%0.330.35%
STRLSterling Infrastructure, Inc. · Engineering & Construction
Higher return, similar volatilityHigher Sharpe, smaller worst declineSmaller losses in recent crashes+74.9%60.2%1.23−62.5%+4,686%0.26—
XOMExxonmobil Holdings Corporation · Integrated Oil & Gas
Similar return, lower volatilityHigher Sharpe, smaller worst decline+27.5%26.5%1.05−61.0%+216%-0.06—
DXJWisdomTree Japan Hedged Equity Fund · Japan Equity
On the frontierHigher Sharpe, smaller worst decline+26.6%19.1%1.34−39.1%+415%0.170.48%
ETONEton Pharmaceuticals, Inc. · Specialty Pharmaceuticals
Higher return in most periods+55.5%66.1%0.99−79.9%—0.26—
What these numbers mean for NTRA
Annual return
NTRA returned 28.4% a year over the past 5 years with dividends reinvested, against 12.5% a year for the S&P 500. At that pace, $10,000 became about $34,900. Annual return is the steady yearly rate that would produce the same total result, so investments held over the same span compare fairly. Guide: What is performance and return? →
Volatility
NTRA's volatility over the past 5 years was 57.6%, 3.4 times the S&P 500's 17.2%. Volatility measures how widely returns swing around their average: in roughly two years out of three, NTRA's return lands within 57.6% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump. Guide: Understanding and measuring risk (volatility) →
Sharpe ratio
NTRA's Sharpe ratio over the past 5 years was 0.73, against 0.78 for the S&P 500, so NTRA earned less for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings. Guide: Balancing reward with risk (Sharpe ratio) →
Worst decline
NTRA's worst fall from a peak to a low over the past 10 years was 77.7%, against 33.7% for the S&P 500. Losses and gains are not symmetric: climbing back from a 77.7% fall takes a 349% gain. Guide: Market crash risk and tail risk →
Correlation
Over the past 5 years, NTRA's monthly returns had a correlation of 0.42 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They often move together: some diversification next to an index fund, but not a cushion. In the table, the correlation column measures each option against NTRA instead: the lower it is, the more that option would diversify a NTRA holding. Guide: Correlation and diversification →
Show all 130 stocks and funds worth at least $500 million that earned more than NTRA with less volatility

Out of 3,641 tested over 5 years. The strongest 100 are listed, best first, with funds that hold the same thing listed once.

#InvestmentFound inAnnual returnVolatilitySharpeWorst decline10Y returnCorr. with NTRAExpense
1
FIXComfort Systems USA, Inc. · Engineering & Construction
Whole market+73.0%46.9%1.41−49.7%+4,888%0.33—
2
PBR-APetróleo Brasileiro S.A. - Petrobras · Integrated Oil & Gas
Whole market+53.5%37.4%1.34−71.7%+733%-0.02—
3
NVDANVIDIA Corporation · Semiconductors
Whole market+56.5%51.9%1.12−66.3%+12,166%0.22—
4
CAHCardinal Health, Inc. · Health Care Distribution
Whole market+41.7%24.7%1.54−46.1%+345%0.30—
5
HWMHowmet Aerospace Inc. · Aerospace Components
Whole market+45.1%32.7%1.31−68.9%+928%0.29—
6
TSMTaiwan Semiconductor Manufacturing Company Limited · Semiconductors
Whole market+31.0%38.6%0.90−56.6%+1,440%0.19—
7
AVGOBroadcom Inc. · Semiconductors
Whole market+46.9%44.6%1.09−48.3%+2,254%0.10—
8
LLYEli Lilly and Company · Pharmaceuticals
Whole market+41.2%32.8%1.22−34.5%+1,870%0.25—
9
HSBCHSBC Holdings plc · Banks
Whole market+32.8%25.9%1.23−62.3%+314%-0.13—
10
CATCaterpillar Inc. · Industrial Machinery
Whole market+30.7%32.0%1.00−43.4%+913%0.23—
11
DELLDell Technologies Inc. · Computer Hardware
Whole market+53.8%54.5%1.06−59.6%+3,613%0.09—
12
MUFGMitsubishi UFJ Financial Group, Inc. · Banks
Whole market+33.5%29.4%1.14−54.9%+485%0.03—
13
INSWInternational Seaways, Inc. · Oil & Gas
Whole market+58.7%40.6%1.35−57.4%—0.05—
14
PANWPalo Alto Networks, Inc. · Cybersecurity
Whole market+33.4%43.4%0.89−48.0%+1,306%0.29—
15
MCKMcKesson Corporation · Health Care Distribution
Whole market+37.8%25.1%1.41−38.1%+582%0.05—
16
ANETArista Networks, Inc. · Communications Equipment
Whole market+47.6%49.1%1.04−52.2%+3,158%0.27—
17
LRCXLam Research Corporation · Semiconductor Equipment
Whole market+34.2%50.1%0.84−56.4%+2,542%0.33—
18
APHAmphenol Corporation · Electronic Components
Whole market+31.3%32.4%1.01−37.5%+887%0.47—
19
BBVABanco Bilbao Vizcaya Argentaria, S.A. · Banks
Whole market+39.0%33.3%1.16−69.6%+515%0.19—
20
STXSeagate Technology Holdings plc · Computer Hardware
Whole market+53.4%48.8%1.12−57.0%+2,597%0.24—
21
VLOValero Energy Corporation · Oil Refining
Whole market+43.8%36.9%1.18−71.9%+1,014%0.02—
22
KLACKLA Corporation · Semiconductor Equipment
Whole market+35.3%46.9%0.88−50.9%+2,224%0.29—
23
IBKRInteractive Brokers Group, Inc. · Investment Banking & Brokerage
Whole market+35.3%35.5%1.03−55.1%+929%0.31—
24
WDCWestern Digital Corporation · Computer Hardware
Whole market+52.5%53.6%1.06−70.5%+889%0.19—
25
MFGMizuho Financial Group, Inc. · Banks
Whole market+33.9%30.6%1.11−45.7%+343%0.12—
26
SCCOSouthern Copper Corporation · Copper Mining
Whole market+30.1%40.8%0.85−55.3%+915%0.00—
27
PSXPhillips 66 · Oil Refining
Whole market+32.7%32.9%1.03−64.2%+413%0.13—
28
SMFGSumitomo Mitsui Financial Group, Inc. · Banks
Whole market+34.0%29.4%1.15−47.6%+470%0.15—
29
ASXASE Technology Holding Co., Ltd. · Semiconductors
Whole market+47.3%43.3%1.11−52.5%+883%0.32—
30
PWRQuanta Services, Inc. · Engineering & Construction
Whole market+36.4%37.4%1.02−45.5%+1,878%0.29—
31
GLWCorning Inc · Electronic Components
Whole market+29.7%42.2%0.83−51.5%+568%0.19—
32
HPEHewlett Packard Enterprise Company · Computer Hardware
Whole market+32.8%42.3%0.89−56.9%+481%0.22—
33
SMHVanEck Semiconductor ETF · Semiconductors
Whole market+32.2%37.0%0.94−45.3%+1,570%0.330.35%
34
VSTVistra Corp. · Independent Power Producers
Whole market+51.7%48.8%1.10−53.3%+1,130%0.32—
35
ESLTElbit Systems Ltd. · Aerospace & Defense
Whole market+39.7%34.6%1.14−35.4%+763%-0.09—
36
CIENCiena Corporation · Communications Equipment
Whole market+43.7%52.9%0.95−49.5%+1,509%0.19—
37
EMEEMCOR Group, Inc. · Engineering & Construction
Whole market+40.8%35.4%1.15−48.0%+1,116%0.30—
38
AUAngloGold Ashanti Plc · Gold Mining
Whole market+38.0%50.0%0.90−66.3%+661%-0.04—
39
STLDSteel Dynamics, Inc. · Steel
Whole market+32.4%38.0%0.93−68.5%+1,019%0.16—
40
BAPCredicorp Ltd. · Banks
Whole market+29.7%30.3%1.01−59.2%+281%0.08—
41
CASYCasey's General Stores, Inc. · Convenience Stores
Whole market+30.8%29.4%1.06−36.1%+560%-0.11—
42
SBSCompanhia de Saneamento Básico do Estado de São Paulo - SABESP · Water Utilities
Whole market+40.9%36.9%1.11−62.0%+282%0.07—
43
JBLJabil Inc. · Electronics Manufacturing
Whole market+34.5%39.7%0.95−57.3%+1,210%0.13—
44
CIBGrupo Cibest S.A. · Banks
Whole market+33.5%32.9%1.04−70.4%+351%0.08—
45
KGCKinross Gold Corporation · Gold Mining
Whole market+31.4%45.6%0.83−67.9%+573%0.02—
46
CWCurtiss-Wright Corporation · Aerospace & Defense
Whole market+29.5%28.8%1.05−48.7%+486%0.20—
47
NVTnVent Electric plc · Electrical Equipment
Whole market+32.5%38.5%0.93−56.2%—0.39—
48
COKECoca-Cola Consolidated, Inc. · Food & Beverages
Whole market+41.6%38.0%1.11−51.7%+1,564%0.19—
49
THCTenet Healthcare Corporation · Health Care Facilities
Whole market+30.8%45.0%0.83−71.7%+1,036%0.34—
50
TSEMTower Semiconductor Ltd. · Semiconductors
Whole market+40.1%52.4%0.90−62.3%+933%0.27—
51
MLIMueller Industries, Inc. · Metal Fabrication
Whole market+36.5%33.4%1.10−53.0%+760%0.21—
52
FROFrontline Plc · Oil & Gas
Whole market+53.9%49.7%1.12−52.0%+1,270%0.08—
53
MOG-AMoog Inc. · Aerospace Components
Whole market+35.1%32.1%1.10−63.7%+540%0.35—
54
AGIAlamos Gold Inc. · Gold Mining
Whole market+31.5%42.4%0.86−66.1%+276%0.05—
55
IDCCInterDigital, Inc. · Intellectual Property Licensing
Whole market+39.4%36.9%1.09−64.9%+392%0.28—
56
JXNJackson Financial Inc. · Life Insurance
Whole market+42.4%43.3%1.04−48.4%—0.22—
57
MPCMarathon Petroleum Corporation · Oil Refining
Whole market+50.0%33.4%1.39−79.7%+1,314%0.08—
58
LAURLaureate Education, Inc. · Education Services
Whole market+36.9%32.8%1.13−64.5%—0.19—
59
SNEXStoneX Group Inc. · Capital Markets
Whole market+32.5%37.3%0.95−48.7%+669%0.11—
60
TRMDTORM plc · Marine Shipping
Whole market+54.8%46.0%1.19−60.6%—0.07—
61
BWLPBW LPG Limited · Marine Shipping
Whole market+60.5%50.9%1.19−68.8%+2,648%0.02—
62
AGXArgan, Inc. · Engineering & Construction
Whole market+52.0%54.1%1.04−58.5%+646%0.08—
63
MIRMMirum Pharmaceuticals, Inc. · Biotechnology
Whole market+40.4%51.7%0.92−63.8%—0.24—
64
NHCNational HealthCare Corporation · Health Care Facilities
Whole market+31.2%28.6%1.10−35.3%+385%0.35—
65
DHTDHT Holdings, Inc. · Oil & Gas
Whole market+40.3%39.0%1.07−39.7%+1,094%0.08—
66
TNKTeekay Tankers Ltd. · Marine Shipping
Whole market+52.2%45.1%1.16−63.4%+511%0.06—
67
GFFGriffon Corporation · Building Products
Whole market+36.9%41.7%0.96−61.3%+774%0.34—
68
TRGPTarga Resources Corp. · Oil & Gas Midstream
Whole market+41.8%31.7%1.27−90.8%+829%0.17—
69
USLMUnited States Lime & Minerals, Inc. · Construction Materials
Whole market+36.8%36.1%1.05−45.9%+831%0.26—
70
LPGDorian LPG Ltd. · Marine Shipping
Whole market+55.8%43.6%1.24−62.9%+1,827%-0.06—
71
HURNHuron Consulting Group Inc. · Consulting Services
Whole market+31.3%40.8%0.87−51.4%+238%0.03—
72
HWKNHawkins, Inc. · Specialty Chemicals
Whole market+29.8%36.6%0.90−44.8%+641%0.25—
73
BLXBladex, Inc. · Banks
Whole market+31.0%25.9%1.18−68.5%+278%0.33—
74
TENTsakos Energy Navigation Limited · Oil & Gas
Whole market+48.0%46.4%1.08−68.7%+225%0.02—
75
ESQEsquire Financial Holdings, Inc. · Regional Banks
Whole market+32.1%31.8%1.04−56.5%—0.06—
76
PLPCPreformed Line Products Company · Electrical Equipment
Whole market+38.3%48.5%0.91−59.5%+733%0.20—
77
ATIATI Inc. · Metals & Mining
Whole market+58.9%43.2%1.29−82.4%+809%0.21—
78
UFPTUFP Technologies, Inc. · Medical Devices
Same or nearby category+36.5%46.0%0.91−48.3%+1,009%0.33—
79
IGICInternational General Insurance Holdings Ltd. · Insurance
Whole market+30.6%30.9%1.02−50.6%—0.04—
80
ODCOil-Dri Corporation of America · Specialty Chemicals
Whole market+36.9%36.9%1.04−48.9%+474%0.16—
81
NBNNortheast Bank · Regional Banks
Whole market+29.7%33.3%0.95−70.2%+1,084%0.00—
82
NWPXNWPX Infrastructure, Inc. · Infrastructure
Whole market+32.7%36.3%0.97−46.5%+619%0.29—
83
ASCArdmore Shipping Corporation · Marine Shipping
Whole market+43.5%44.7%1.03−71.2%+278%-0.07—
84
CLMBClimb Global Solutions, Inc. · Technology Distribution
Whole market+38.4%45.5%0.94−53.4%+886%0.19—
85
GEGE Aerospace · Aerospace & Defense
Whole market+36.0%31.0%1.15−80.9%+135%0.35—
86
PBRPetróleo Brasileiro S.A. - Petrobras · Integrated Oil & Gas
Whole market+52.4%37.4%1.32−75.3%+647%-0.07—
87
SANBanco Santander, S.A. · Banks
Whole market+31.7%33.9%0.99−73.8%+307%0.10—
88
BELFBBel Fuse Inc. · Electronic Components
Whole market+75.9%52.3%1.35−79.8%+818%0.07—
89
SUSuncor Energy Inc. · Integrated Oil & Gas
Whole market+33.1%32.5%1.05−73.5%+289%-0.04—
90
IMOImperial Oil Limited · Integrated Oil & Gas
Whole market+33.7%32.0%1.07−77.1%+411%-0.05—
91
FTITechnipFMC plc · Oilfield Services
Whole market+54.6%41.2%1.27−85.8%+173%0.03—
92
TEVATeva Pharmaceutical Industries Limited · Specialty Pharmaceuticals
Whole market+31.7%42.8%0.85−85.3%−3.6%0.26—
93
YPFYPF Sociedad Anónima · Integrated Oil & Gas
Whole market+61.5%54.1%1.15−90.1%+164%0.33—
94
GFIGold Fields Limited · Gold Mining
Whole market+34.0%53.5%0.82−56.2%+1,041%-0.13—
95
FLEXFlex Ltd. · Electronics Manufacturing
Whole market+32.7%48.5%0.83−70.0%+457%0.21—
96
CRSCarpenter Technology Corporation · Metals & Mining
Whole market+57.4%47.4%1.20−74.7%+775%0.22—
97
DINOHF Sinclair Corporation · Oil Refining
Whole market+31.8%38.8%0.91−77.3%+596%0.01—
98
UNMUnum Group · Life Insurance
Whole market+31.4%29.3%1.08−81.0%+263%-0.01—
99
XPOXPO Logistics, Inc. · Trucking
Whole market+30.0%47.0%0.79−64.5%+1,487%0.24—
100
PRPermian Resources Corporation · Exploration & Production
Whole market+31.5%47.0%0.82−98.9%+95.0%0.15—

NTRA against its popular alternatives

The investments people most often weigh against NTRA, compared period by period and year by year.

How do NTRA's risk and return compare with its alternatives?

This map plots each investment's annual return over the past 5 years against its volatility, the size of its typical price swings. Investments toward the upper left earned more for a smoother ride, and those toward the lower right earned less for a rougher one. The dashed lines cross at NTRA, which divides the map into what did better or worse on each measure.

Green points earned more than NTRA with less volatility; red points earned less with more. Hover over a point for its figures. Total returns with dividends reinvested, annualized.

0.0%20.0%40.0%60.0%80.0%100%120%−40.0%−30.0%−20.0%−10.0%0.0%10.0%20.0%30.0%Volatility over 5 years (annualized)Annual return over 5 yearsHigher return, lower volatilityLower return, higher volatilityNTRA: 28.4% a year, volatility 57.6%SPY (S&P 500): 12.5% a year, volatility 17.2%CDNA: −0.8% a year, volatility 79.5%PSNL: −3.5% a year, volatility 103%TXG: −15.7% a year, volatility 70.9%VCYT: −0.2% a year, volatility 64.8%NEO: −18.3% a year, volatility 70.3%MYGN: −29.2% a year, volatility 68.3%PACB: −39.5% a year, volatility 97.1%GH: 8.3% a year, volatility 67.9%ADPT: −6.2% a year, volatility 78.7%ILMN: −7.5% a year, volatility 47.0%DGX: 13.0% a year, volatility 22.5%DHR: −3.2% a year, volatility 29.2%LH: 7.5% a year, volatility 23.9%QGEN: 0.8% a year, volatility 26.9%BDX: 3.0% a year, volatility 24.1%RGEN: −8.3% a year, volatility 51.3%TMO: 2.3% a year, volatility 27.8%NTRASPY (S&P 500)CDNAPSNLTXGVCYTNEOMYGNPACBGHADPTILMNDHRLHQGENBDX0.0%20.0%40.0%60.0%80.0%100%120%−40.0%−20.0%0.0%20.0%40.0%Volatility over 5 years (annualized)Annual return over 5 yearsHigher return, lower volatilityLower return, higher volatilityNTRA: 28.4% a year, volatility 57.6%SPY (S&P 500): 12.5% a year, volatility 17.2%CDNA: −0.8% a year, volatility 79.5%PSNL: −3.5% a year, volatility 103%TXG: −15.7% a year, volatility 70.9%VCYT: −0.2% a year, volatility 64.8%NEO: −18.3% a year, volatility 70.3%MYGN: −29.2% a year, volatility 68.3%PACB: −39.5% a year, volatility 97.1%GH: 8.3% a year, volatility 67.9%ADPT: −6.2% a year, volatility 78.7%ILMN: −7.5% a year, volatility 47.0%DGX: 13.0% a year, volatility 22.5%DHR: −3.2% a year, volatility 29.2%LH: 7.5% a year, volatility 23.9%QGEN: 0.8% a year, volatility 26.9%BDX: 3.0% a year, volatility 24.1%RGEN: −8.3% a year, volatility 51.3%TMO: 2.3% a year, volatility 27.8%NTRASPY (S&P 500)CDNAPSNLTXGVCYTNEOMYGNPACBGHADPTILMNDGXDHRLHQGENBDXRGEN
All figures
InvestmentAnnual returnVolatility
NTRA This pageNatera, Inc.+28.4%57.6%
DGX Quest Diagnostics Incorporated+13.0%22.5%
SPY S&P 500State Street SPDR S&P 500 ETF+12.5%17.2%
GH Guardant Health, Inc.+8.3%67.9%
LH Labcorp Holdings Inc.+7.5%23.9%
BDX Becton, Dickinson and Company+3.0%24.1%
TMO Thermo Fisher Scientific Inc.+2.3%27.8%
QGEN Qiagen N.V.+0.8%26.9%
VCYT Veracyte, Inc.−0.2%64.8%
CDNA CareDx, Inc−0.8%79.5%
DHR Danaher Corporation−3.2%29.2%
PSNL Personalis, Inc.−3.5%103%
ADPT Adaptive Biotechnologies Corporation−6.2%78.7%
ILMN Illumina, Inc.−7.5%47.0%
RGEN Repligen Corporation−8.3%51.3%
TXG 10x Genomics, Inc.−15.7%70.9%
NEO NeoGenomics, Inc.−18.3%70.3%
MYGN Myriad Genetics, Inc.−29.2%68.3%
PACB Pacific Biosciences of California, Inc.−39.5%97.1%
Open these 19 in EasyCompare

Has NTRA consistently beaten its popular alternatives?

This section compares NTRA with the investments people most often weigh against it, checking each one over eight periods from one month to ten years. Counting how often an alternative earned more than NTRA helps separate lasting outperformance from a single strong stretch.

A green cell means the alternative earned more than NTRA over that period. "Qualified" marks those that did so in at least 3 of 5 short-term periods and 2 of 3 long-term periods.

InvestmentPeriods outperformed Short termLong termRisk · 5 yearsFund
1M3M6MYTD1Y3Y5Y10YVolatilitylower is calmerSharpehigher is betterWorst declinepast 10 yearsExpenseAssetsOverlapsame sectors
NTRA Natera, Inc. (this page)—+2.7%+51.9%+93.2%+75.4%+113%+901%+249%+3,934%57.6%0.73−77.7%—$58B—
CDNA Medical - Diagnostics & ResearchCareDx, Inc5/5 short1/3 long+22.4%+83.1%+235%+261%+374%+1,227%−4.1%+1,687%79.5%0.39−94.9%—$3.6B—
PSNL Medical - Diagnostics & ResearchPersonalis, Inc.2/5 short1/3 long−3.3%+26.9%+151%+102%+77.2%+1,601%−16.5%—103%0.46−98.2%—$1.7B—
ILMN Medical - Diagnostics & ResearchIllumina, Inc.4/5 short0/3 long+8.9%+41.1%+106%+101%+177%+132%−32.2%+94.8%47.0%0.07−86.2%—$41B—
TXG Biotechnology10x Genomics, Inc.3/5 short0/3 long−13.6%+48.2%+206%+320%+469%+75.0%−57.5%—70.9%0.11−96.5%—$9.1B—
VCYT Medical - Diagnostics & ResearchVeracyte, Inc.1/5 short0/3 long+6.2%−20.6%+36.6%+8.6%+32.5%+122%−0.8%+466%64.8%0.32−81.2%—$3.7B—
DGX Medical - Diagnostics & ResearchQuest Diagnostics Incorporated1/5 short0/3 long+4.1%+16.5%+20.3%+42.5%+36.7%+112%+84.0%+256%22.5%0.66−36.6%—$27B—
DHR Medical - Diagnostics & ResearchDanaher Corporation1/5 short0/3 long+4.1%+28.5%+25.3%+0.3%+6.1%+14.6%−15.2%+240%29.2%0.03−43.8%—$161B—
LH Medical - Diagnostics & ResearchLabcorp Holdings Inc.1/5 short0/3 long+5.9%+17.5%+21.6%+32.1%+17.8%+72.6%+43.6%+190%23.9%0.42−46.6%—$27B—
NEO Medical - Diagnostics & ResearchNeoGenomics, Inc.1/5 short0/3 long−13.2%+17.0%+100%+39.4%+58.5%+19.5%−63.5%+120%70.3%0.07−91.9%—$2.1B—
QGEN Medical - Diagnostics & ResearchQiagen N.V.1/5 short0/3 long+14.9%+23.8%+26.8%+11.7%+9.3%+50.5%+4.2%+118%26.9%0.16−41.4%—$10B—
BDX Medical - Instruments & SuppliesBecton, Dickinson and Company1/5 short0/3 long+9.5%+31.6%+30.4%+33.3%+38.9%+6.2%+16.0%+78.1%24.1%0.25−39.9%—$55B—
MYGN Medical - Diagnostics & ResearchMyriad Genetics, Inc.1/5 short0/3 long+43.3%+1.8%+13.4%−6.2%−26.7%−62.3%−82.3%−70.8%68.3%-0.15−94.3%—$551M—
PACB Medical - DevicesPacific Biosciences of California, Inc.1/5 short0/3 long+40.1%+49.3%+20.5%+12.0%+12.0%−71.6%−91.9%−77.1%97.1%-0.03−98.2%—$640M—
GH Medical - Diagnostics & ResearchGuardant Health, Inc.1/5 short0/3 long−8.0%+8.1%+81.9%+60.2%+140%+527%+49.0%—67.9%0.46−91.0%—$22B—
RGEN Medical - Instruments & SuppliesRepligen Corporation0/5 short0/3 long−4.3%+27.6%+43.7%+8.7%+13.5%+24.3%−35.0%+511%51.3%0.09−68.3%—$11B—
TMO Medical - Diagnostics & ResearchThermo Fisher Scientific Inc.0/5 short0/3 long+2.7%+28.6%+31.9%+14.5%+19.7%+47.9%+12.1%+355%27.8%0.22−40.9%—$250B—
ADPT BiotechnologyAdaptive Biotechnologies Corporation0/5 short0/3 long−13.0%+11.2%+71.9%+53.4%+48.4%+484%−27.4%—78.7%0.30−96.5%—$3.9B—
Open these 18 in EasyCompare

How did NTRA do year by year?

This table shows each investment's total return in every full calendar year since 2016, along with where NTRA ranked among its popular alternatives each year. Annual results reveal how consistently each one kept pace with NTRA and how far its good and bad years diverged, detail that multiyear averages tend to smooth over.

Note: NTRA began trading on July 1, 2015, so the table starts with 2016, its first full calendar year, and cannot show how it fared during the dot-com bust, the 2008 financial crisis or two other sell-offs.

Newest year first. Green marks a year in which the fund came out ahead of NTRA; gray means the two finished within a fraction of a point. The rank row places NTRA among the alternatives that traded the full year; dark green is the top quarter and red the bottom quarter.

InvestmentYears ahead of NTRA2025202420232022202120202019201820172016
NTRA This pageNatera, Inc.—+44.7%+153%+55.9%−57.0%−6.2%+195%+141%+55.3%−23.2%+8.4%
Rank among alternativesTop quarter in 6 of 103 of 182 of 182 of 1811 of 1811 of 184 of 181 of 154 of 1413 of 146 of 14
SPY S&P 500State Street SPDR S&P 500 ETF4 of 10+17.7%+24.9%+26.2%−18.2%+28.7%+18.3%+31.2%−4.6%+21.7%+12.0%
CDNA CareDx, Inc3 of 10−12.0%+78.4%+5.2%−74.9%−37.2%+236%−14.2%+243%+172%−57.8%
PSNL Personalis, Inc.2 of 6+37.7%+175%+6.1%−86.1%−61.0%+236%————
ILMN Illumina, Inc.3 of 10−1.8%−1.3%−31.1%−46.9%+2.8%+11.5%+10.6%+37.3%+70.7%−33.3%
TXG 10x Genomics, Inc.1 of 6+13.6%−74.3%+53.6%−75.5%+5.2%+85.7%————
VCYT Veracyte, Inc.3 of 10+6.3%+44.0%+15.9%−42.4%−15.8%+75.3%+122%+92.7%−15.6%+7.5%
DGX Quest Diagnostics Incorporated4 of 10+17.2%+11.8%−10.1%−7.4%+47.9%+14.1%+31.1%−13.8%+9.1%+31.9%
DHR Danaher Corporation4 of 10+0.4%−0.4%−1.2%−19.0%+48.6%+45.4%+49.5%+11.8%+20.0%+73.2%
LH Labcorp Holdings Inc.3 of 10+10.6%+2.2%+13.8%−24.4%+54.4%+20.3%+33.9%−20.8%+24.3%+3.8%
NEO NeoGenomics, Inc.2 of 10−28.6%+1.9%+75.1%−72.9%−36.6%+85.5%+132%+42.3%+3.4%+8.8%
QGEN Qiagen N.V.3 of 10+12.5%+2.6%−12.9%−10.3%+5.2%+56.4%−1.9%+11.4%+10.7%+1.3%
BDX Becton, Dickinson and Company4 of 10−12.5%−5.3%−2.7%+5.1%+1.9%−6.8%+22.2%+6.6%+31.2%+9.2%
MYGN Myriad Genetics, Inc.3 of 10−55.1%−28.4%+31.9%−47.4%+39.6%−27.4%−6.3%−15.4%+106%−61.4%
PACB Pacific Biosciences of California, Inc.2 of 10+2.2%−81.3%+19.9%−60.0%−21.1%+405%−30.5%+180%−30.5%−71.1%
GH Guardant Health, Inc.1 of 7+234%+12.9%−0.5%−72.8%−22.4%+64.9%+108%———
RGEN Repligen Corporation4 of 10+13.8%−20.0%+6.2%−36.1%+38.2%+107%+75.4%+45.4%+17.7%+8.9%
TMO Thermo Fisher Scientific Inc.3 of 10+11.8%−1.7%−3.4%−17.3%+43.5%+43.7%+45.6%+18.2%+35.0%−0.1%
ADPT Adaptive Biotechnologies Corporation1 of 6+171%+22.4%−35.9%−72.8%−52.5%+97.6%————
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Risk and diversification

How NTRA has fallen, how it held up in crashes beside the S&P 500 and its popular alternatives, and what moves independently of it.

What were NTRA's worst declines?

A drawdown is the decline from a peak to the lowest point before a new high. This section presents NTRA's five deepest drawdowns since it began trading in 2015, alongside the S&P 500's return over the same dates, and how long each took to recover. Together, these figures show how much an investor could have lost and how long it took to get back to even.

Note: NTRA began trading on July 1, 2015, so this list cannot include the dot-com bust, the 2008 financial crisis or two other sell-offs. The crash tests on this page show how older funds and the S&P 500 fared through those years.

Green means NTRA fell less than the S&P 500 over the same dates. Based on daily closing prices with dividends reinvested.

DuringNTRA fellS&P 500, same datesPeakLowTime to the lowBack at the peakTime to recover
2022 bear market−77.7%−10.4%Sep 2021May 20228 monthsSep 20242.3 years
2015 China and oil sell-off−70.0%−9.3%Jul 2015Feb 20167 monthsJul 20182.4 years
Late-2018 sell-off−60.8%−9.3%Aug 2018Jan 20195 monthsAug 20197 months
Covid crash−57.3%−22.7%Nov 2019Mar 20204 monthsMay 20202 months
No named crash−30.8%+6.0%Feb 2021May 20213 monthsSep 20214 months

How did NTRA do in stock market crashes?

This section measures how far NTRA, the S&P 500 and each alternative fell from peak to trough during every major market crash since 2000. A smaller decline means an investment held up better, and comparing results across crashes shows whether that resilience was consistent or a one-off.

Note: NTRA began trading on July 1, 2015, so its row reads "Not yet trading" for the dot-com bust, the 2008 financial crisis or two other sell-offs. The older alternatives and the S&P 500 show how those crashes played out.

Newest crash first. Each figure is the fund's deepest fall within the crash window; green means a smaller fall than NTRA.

InvestmentHeld up better2023 regional bank crisisMar 20232022 bear marketJan 2022Covid crashFeb 2020Late-2018 sell-offSep 2018February 2018 volatility shockFeb 20182015 China and oil sell-offAug 20152011 euro debt crisisJul 20112010 flash crashMay 20102008 financial crisisOct 2007Dot-com bustMar 2000
NTRA This pageNatera, Inc.—−6.2%−68.0%−57.0%−51.1%−11.2%−61.5%Not yet tradingNot yet tradingNot yet tradingNot yet trading
SPY S&P 500State Street SPDR S&P 500 ETF6 of 6−3.4%−24.5%−33.7%−19.3%−6.5%−12.8%−17.9%−1.5%−55.2%−47.5%
CDNA CareDx, Inc5 of 6−10.8%−65.3%−50.6%−33.7%−2.9%−42.7%————
PSNL Personalis, Inc.1 of 3−17.8%−80.6%−54.7%———————
ILMN Illumina, Inc.5 of 6−6.7%−58.2%−31.0%−25.8%−5.3%−36.1%−48.7%−1.9%−57.9%—
TXG 10x Genomics, Inc.1 of 3−8.1%−81.1%−43.1%———————
VCYT Veracyte, Inc.5 of 6−11.3%−59.1%−39.7%−25.1%−10.0%−53.7%————
DGX Quest Diagnostics Incorporated6 of 6−2.7%−22.3%−35.0%−26.1%−6.5%−17.8%−19.3%−1.0%−29.2%−46.6%
DHR Danaher Corporation6 of 6−3.2%−22.8%−25.9%−13.4%−9.8%−14.0%−21.8%−0.6%−45.7%−33.7%
LH Labcorp Holdings Inc.6 of 6−4.7%−29.6%−45.5%−30.6%−3.8%−19.5%−18.4%−1.4%−33.5%−63.1%
NEO NeoGenomics, Inc.4 of 6−7.2%−78.5%−40.5%−39.3%−7.0%−29.2%−30.6%−2.8%−62.7%—
QGEN Qiagen N.V.6 of 6−0.4%−21.3%−12.4%−14.0%−7.0%−27.8%−25.9%−2.6%−45.1%−92.1%
BDX Becton, Dickinson and Company5 of 6−2.0%−19.7%−21.8%−20.4%−10.8%−15.1%−18.3%−1.6%−34.1%—
MYGN Myriad Genetics, Inc.6 of 6−2.8%−40.8%−51.1%−42.0%−9.8%−26.1%−23.4%−0.2%−40.3%−89.6%
PACB Pacific Biosciences of California, Inc.4 of 6−6.7%−79.3%−47.4%−28.1%−10.0%−34.7%−75.2%———
GH Guardant Health, Inc.1 of 3−13.4%−70.6%−33.5%———————
RGEN Repligen Corporation6 of 6−4.9%−38.7%−22.2%−29.9%−8.6%−44.4%−17.1%−3.7%−51.9%−90.7%
TMO Thermo Fisher Scientific Inc.6 of 6−2.4%−19.8%−24.8%−17.2%−8.7%−14.7%−24.4%−3.6%−53.9%−41.8%
ADPT Adaptive Biotechnologies Corporation1 of 3−10.0%−75.8%−50.3%———————
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How closely does NTRA move with the S&P 500?

Upside capture measures how much of the S&P 500's gains an investment kept in the months the market rose, and downside capture how much of its losses it took in the months the market fell. An investment that captures more of the gains than the losses has compounded ahead of the market over time. This section compares NTRA with its popular alternatives on both measures, and on beta (how strongly each has moved with the market), over the past 10 years.

Monthly total returns over the past 10 years, measured against SPY. 100% capture or a beta of 1.00 means moving in line with the S&P 500. Green marks a better figure than NTRA's: more upside, less downside or a higher capture ratio. Sorted by capture ratio.

InvestmentUpside captureDownside captureCapture ratioBeta
NTRA This pageNatera, Inc.169%82%2.061.40
DGX Quest Diagnostics Incorporated69%54%1.280.80
CDNA CareDx, Inc186%161%1.161.56
RGEN Repligen Corporation119%108%1.110.99
DHR Danaher Corporation84%84%1.010.75
VCYT Veracyte, Inc.128%128%1.001.41
TMO Thermo Fisher Scientific Inc.104%104%1.000.81
LH Labcorp Holdings Inc.81%91%0.890.97
QGEN Qiagen N.V.62%83%0.750.45
BDX Becton, Dickinson and Company53%77%0.690.48
NEO NeoGenomics, Inc.116%169%0.681.26
ILMN Illumina, Inc.120%200%0.601.19
PACB Pacific Biosciences of California, Inc.76%234%0.331.70
MYGN Myriad Genetics, Inc.68%233%0.291.63
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What diversifies NTRA?

Correlation measures how closely two investments move together, on a scale from 1 (in lockstep) through 0 (unrelated) to -1 (in opposite directions). This section lists large ETFs and stocks whose returns have had a low correlation with NTRA's. Because such investments tend not to fall at the same time, pairing NTRA with them can reduce a portfolio's overall swings.

Only ETFs with at least $1.0B in assets and stocks worth at least $10B, with a correlation below 0.5 over the past 5 years and a positive return, are included, ranked by Sharpe ratio; funds that hold the same thing are shown once. The year columns are the years in which NTRA lost money. The last two columns show a portfolio that is 80% NTRA and 20% the other investment, rebalanced monthly.

ETFs

InvestmentCorrelation5Y returnSharpe20222021201780/20 mix volatility80/20 mix annual return
NTRA Natera, Inc. (this page)1.00+249%0.73−57.0%−6.2%−23.2%55.5%+30.0%
LVHI InternationalFranklin International Low Volatility High Dividend Index ETF0.11+119%1.48+3.8%+17.8%+10.0%44.6%+30.3%
DXJ InternationalWisdomTree Japan Hedged Equity Fund0.17+225%1.34+6.0%+18.0%+22.8%44.9%+32.4%
EMLP Broad MarketFirst Trust North American Energy Infrastructure Fund0.17+103%1.06+10.4%+23.1%+1.1%45.0%+30.0%
HDV Dividend & IncomeiShares Core High Dividend ETF0.13+86.8%1.03+7.0%+19.6%+13.3%44.9%+29.2%
DBEF InternationalXtrackers MSCI EAFE Hedged Equity ETF0.31+83.6%0.95−5.1%+19.6%+16.7%45.1%+29.3%
SMH TechnologyVanEck Semiconductor ETF0.33+304%0.94−33.5%+42.1%+38.5%47.2%+34.5%
XLE EnergyState Street Energy Select Sector SPDR ETF-0.04+178%0.94+64.4%+53.3%−0.9%44.5%+32.5%
GLD CommoditiesSPDR Gold Shares-0.07+120%0.93−0.8%−4.2%+12.8%44.3%+31.0%

Stocks

InvestmentCorrelation5Y returnSharpe20222021201780/20 mix volatility80/20 mix annual return
NTRA Natera, Inc. (this page)1.00+249%0.73−57.0%−6.2%−23.2%55.5%+30.0%
CAH Medical - DistributionCardinal Health, Inc.0.30+471%1.54+54.1%−0.4%−12.7%46.3%+34.6%
CLS Hardware, Equipment & PartsCelestica Inc.0.22+2,780%1.43+1.3%+37.9%−11.6%48.3%+48.7%
MCK Medical - DistributionMcKesson Corporation0.05+397%1.41+51.8%+44.2%+12.0%44.9%+34.6%
FIX Engineering & ConstructionComfort Systems USA, Inc.0.33+1,452%1.41+17.0%+89.0%+32.1%48.1%+43.8%
MPC Oil & Gas Refining & MarketingMarathon Petroleum Corporation0.08+660%1.39+86.6%+61.0%+34.8%45.4%+37.5%
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Common questions

What was NTRA's worst drawdown?

NTRA's deepest decline since it began trading in 2015 was 77.7%, from September 2021 to May 2022. It took 28 months from the low to climb back to its old high. Because NTRA launched in July 2015, that record does not include the dot-com bust, the 2008 financial crisis or two other sell-offs.

What were NTRA's best and worst years?

Over ten full calendar years, NTRA's best year was 2020, when it returned 195%. Its worst was 2022, with a return of -57.0%.

Is there a better investment than NTRA?

Looking beyond its popular alternatives, UFPT (medical devices) and GKOS (medical devices) earned more than NTRA with less volatility over the past 5 years. UFPT returned 36.5% a year at 46.0% volatility, against 28.4% a year at 57.6%. Across the whole market, 130 of the 3,641 stocks and funds worth at least $500 million earned more than NTRA with less volatility over the past 5 years, among them NVDA, TSM and AVGO.

Is NTRA more volatile than the S&P 500?

Yes. NTRA's volatility over the past 5 years was 57.6%, 3.4 times the S&P 500's 17.2%. Volatility measures how widely returns swing around their average: in roughly two years out of three, NTRA's return lands within 57.6% of its average, either way. The higher it is, the rougher the ride and the harder it is to hold through a slump.

What is NTRA's Sharpe ratio?

NTRA's Sharpe ratio over the past 5 years was 0.73, against 0.78 for the S&P 500, so NTRA earned less for each unit of risk than an index fund did. The Sharpe ratio is the return earned above cash for each unit of volatility: two investments with the same return are not equal if one got there with far bigger swings.

How correlated is NTRA with the S&P 500?

Over the past 5 years, NTRA's monthly returns had a correlation of 0.42 with the S&P 500. Correlation runs from 1 (moving in lockstep) through 0 (unrelated) to −1 (moving in opposite directions). They often move together: some diversification next to an index fund, but not a cushion. In the table, the correlation column measures each option against NTRA instead: the lower it is, the more that option would diversify a NTRA holding.

What are the best alternatives to NTRA?

None of the 17 popular alternatives we compared outperformed NTRA in at least 3 of 5 short-term and 2 of 3 long-term timeframes, which says more about NTRA's strength than about its alternatives.

Did NTRA outperform the S&P 500?

NTRA finished ahead of the S&P 500 (SPY) in six of ten full calendar years. In 2025, it returned +44.7%, against +17.7% for the index.

How did NTRA do in stock market crashes?

NTRA fell less than the S&P 500 (SPY) in none of the six major crashes it has traded through, and further in six. The clearest case was the 2015 China and oil sell-off, when NTRA fell 61.5% and the S&P 500 fell 12.8%.

What diversifies NTRA?

These had a low correlation with NTRA over the past 5 years and still earned a positive 5-year return: among large ETFs, LVHI (correlation 0.11), DXJ (correlation 0.17) and EMLP (correlation 0.17); among large stocks, CAH (correlation 0.30), CLS (correlation 0.22) and MCK (correlation 0.05). A correlation near zero means the two have moved largely independently.

How we measure

More research

Popular alternatives to NTRA

Other stocks and ETFs